Passive anal intercourse as a risk factor for AIDS in homosexual men.

AIDS Activity, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333, U.S.A.
The Lancet (Impact Factor: 39.06). 08/1983; 2(8342):160. DOI: 10.1016/S0140-6736(83)90139-3
Source: PubMed
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    ABSTRACT: Commercial sex venues such as bathhouses and sex clubs have long been considered important facilitators of HIV transmission among men who have sex with men in the United States. Recent probability surveys of commercial-sex-venue patrons in King County, WA that included data on behavior both within and outside these venues provide an empirical basis for the development of mathematical models to estimate the role that commercial sex venues play in the HIV epidemic. We constructed deterministic compartmental mathematical models of HIV transmission to estimate both current incidence among King County men who have sex with men and incidence in 5 counterfactual scenarios in which commercial-sex-venues were presumed not to exist. We parameterized the models using a range of values for the proportion of commercial sex venues partnerships replaced in the absence of these venues, and the number of acts of unprotected anal intercourse per other types of partnership. Yearly attributable number was calculated as the difference between incident HIV cases in the main models and each corresponding counterfactual model. We performed extensive sensitivity analyses using Latin hypercube sampling. Replacement of 25% of commercial sex venue partners in the absence of these venues resulted in attributable number values near zero per year. Replacement of 50% or more of commercial sex venue partners resulted in negative yearly attributable numbers, indicating a net increase in incident HIV infections in the absence of these venues. Results of the sensitivity analyses were consistent with the main findings. Our findings imply that commercial sex venues contribute little to the burden of HIV among men who have sex with men in King County, WA.
    Epidemiology (Cambridge, Mass.) 04/2010; 21(3):349-59. · 5.51 Impact Factor
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    Public health 11/2012; · 1.26 Impact Factor
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    ABSTRACT: In Australia, HIV is concentrated in men who have sex with men (MSM) and rates have increased steadily over the past ten years. Health promotion strategies should ideally be informed by an understanding of both the prevalence of the factors being modified, as well as the size of the risk that they confer. We undertook an analysis of the potential population impact and cost saving that would likely result from modifying key HIV risk factors among men who have sex with men (MSM) in Sydney, Australia. Proportional hazard analyses were used to examine the association between sexual behaviours in the last six months and sexually transmissible infections on HIV incidence in a cohort of 1426 HIV-negative MSM who were recruited primarily from community-based sources between 2001 and 2004 and followed to mid-2007. We then estimated the proportion of HIV infections that would be prevented if specific factors were no longer present in the population, using a population attributable risk (PAR) method which controls for confounding among factors. We also calculated the average lifetime healthcare costs incurred by the HIV infections associated with specific factors by estimating costs associated with clinical care and treatment following infection and discounting at 3% (1% and 5% sensitivity) to present value. Unprotected anal intercourse (UAI) with a known HIV-positive partner was reported by 5% of men, the hazard ratio (HR) was 16.1 (95%CI:6.4-40.5), the PAR was 34% (95%CI:24-44%) and the average lifetime HIV-related healthcare costs attributable to UAI with HIV-positive partners were $AUD102 million (uncertainty range: $93-114 m). UAI with unknown HIV status partners was reported by 25% of men, the HR was 4.4 (95%CI:1.8-11.2), the PAR was 33% (95%CI:26-42%) and the lifetime incurred costs were $AUD99 million. Anal warts prevalence was 4%, the HR was 5.2 (95%CI:2.4-11.2), the PAR was 13% (95%CI:9-19%) and the lifetime incurred costs were $AUD39 million. Our analysis has found that although UAI with an HIV-positive sexual partner is a relatively low-prevalence behaviour (reported by 5% of men), if this behaviour was not present in the population, the number of infections would be reduced by one third. No other single behaviour or sexually transmissible infections contributes to a greater proportion of infections and HIV-related healthcare costs.
    BMC Public Health 01/2011; 11:247. · 2.08 Impact Factor