• Progress in Neurobiology 02/1991; 36(3):171-94. DOI:10.1016/0301-0082(91)90029-Z · 10.30 Impact Factor
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    ABSTRACT: A 9 to 10 year follow-up study of 34 female alcoholics was carried out. 21 subjects were interviewed and completed a questionnaire and limited information was obtained on a further 4 subjects. Various aspects of outcome are reported on including: abstinence, prescribed drug abuse, morbidity, marital status and attitudes to agencies that provide help for alcoholics. Six of the subjects died during the follow-up period, two committed suicide. The study supports most of the accepted ideas about female alcoholism but emphasises the problems of suicide, prescribed drug abuse and marital separation. The relevant literature is reviewed. There is a relative paucity of information about alcoholism in females in the literature despite the increased incidence (1,2). Follow-up studies of alcoholics, as with other chronic disorders, help to add to knowledge about the natural history of the disorder and give information about associated problems. A 10 year literature search failed to find a follow-up study of Irish Female Alcoholics.
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    ABSTRACT: Alcohol dependence was induced in C57BL/6J mice by administration of a liquid diet containing ethanol. These mice showed alcohol withdrawal signs when the alcohol diet was withdrawn. However, when the alcohol diet was substituted with three liquid diets containing different amounts of chlordiazepoxide (CDP; 0.4, 1 and 2 mg/ml), the alcohol withdrawal signs were fully suppressed by CDP. The CDP diet administration was continued for 14-24 days. At termination of the diet treatment, the mice showed CDP withdrawal signs. Similar signs, but much more short-lived, can be precipitated by injection of the benzodiazepine receptor antagonist, RO-15-1788. The results are consistent with the hypothesis that alcohol-dependent mice are cross-dependent on CDP. This report constitutes the first experimental demonstration of cross-dependence between ethanol and CDP. The reverse phenomenon, namely, CDP-dependent mice being cross-dependent on ethanol, remains to be investigated.
    Alcohol 09/1986; 3(5):309-16. DOI:10.1016/0741-8329(86)90007-8 · 2.04 Impact Factor