Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study.
ABSTRACT A signet-ring cell adenocarcinoma of rectum removed from a 71-year-old woman was examined by light and electron microscopy. Most of the mucin in the signet-ring cells was of the neutral type, although acidic, mostly non-sulphated, mucin was also present. Three other types of neoplastic cells. The similarities between this tumour and tumours described in the stomach, appendix and breast care discussed.
Article: Mixed adenocarcinoma and carcinoid tumour of the colon. A report of 4 cases with postulates on histogenesis.[show abstract] [hide abstract]
ABSTRACT: Gastro-intestinal tumours which contain both mucinous and endocrine cells have been reported with increasing frequency recently. Four such mixed neoplasms of the colon are described. Macroscopically, the tumours caused muscular hypertrophy resulting in thickening of the wall of the bowel and annular stenosis of the lumen. Microscopic examination showed them to be poorly differentiated adenocarcinomas with a distinct carcinoid component. Both the mucinous and endocrine elements were demonstrated in metastatic deposits of the tumour, so confirming the malignant nature of each component. The neoplasms appear to represent a distinct clinico-pathological entity associated with a poor prognosis. The histogenesis is postulated to be a range of neoplasms from pure adenocarcinoma through mixed tumours to pure carcinoids and small-cell undifferentiated carcinoma. Such mixed tumours could arise from neoplastic change of crypt-base stem cells.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 12/1987; 72(10):708-10. · 2.04 Impact Factor