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Positron emission tomographic studies of aging and Alzheimer disease. AJNR Am J Neuroradiol 4:568-571

American Journal of Neuroradiology (Impact Factor: 3.68). 05/1983; 4(3):568-71.
Source: PubMed

ABSTRACT In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

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    • "Early studies utilizing PET indicated that brain metabolism throughout the cortex in AD patients is significantly lower than cortical metabolism in normal subjects [11] [12]. Clinical data from PET studies have shown which areas of the brain are mostly affected by mild and moderate AD, such as the posterior cingulate cortex, parietotemporal cortex, and prefrontal association cortices [13]. "
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    03/2011; 2011:104545. DOI:10.4061/2011/104545
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    • "Identification of the molecular mechanisms underlying these processes is essential for the development of rational therapeutics to treat or prevent this disorder. Numerous studies have linked impaired energy metabolism to AD (Craft and Watson, 2004; de Leon et al., 1983; Hoyer, 2004; Rapoport, 1999a, b; Steen et al., 2005). Studies of postmortem AD brains have also shown increased BACE1 levels compared with age-matched, nondemented controls (Fukumoto et al., 2002; Holsinger et al., 2002; Li et al., 2004; Sennvik et al., 2004; Tyler et al., 2002; Yang et al., 2003; Zhao et al., 2007). "
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    • "The significant decrement in glucose metabolic rates for the Alzheimer subjects compared to age­ matched controls is consistent with our earlier J Cereb Blood Flow Metab, Vol. 7, No.2, 1987 studies (Ferris et aI., 1980; de Leon et aI., 1983) and those of others (Benson et aI., 1983). However, the similar diminution in frontal, temporal, and parietal activity found in the present study is in disagree­ ment with the more marked decreases found in the parietotemporal area relative to frontal lobe sam­ ples reported by other investigators (Chase et aI., 1983; Friedland et aI., 1983). "
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