Secretory carcinoma of the breast. Cancer

Cancer (Impact Factor: 4.9). 05/1980; 45(9):2404-13. DOI: 10.1002/1097-0142(19800501)45:9<2404::AID-CNCR2820450928>3.0.CO;2-8
Source: PubMed

ABSTRACT Nineteen examples of a very rare type of carcinoma of the breast have been studied. The carcinoma is unusual in that it has exaggerated secretory features previously reported only (with one exception) in juveniles. But not all the patients in our series were juveniles; they ranged in age from 9 to 69 years (median age, 25 years). Six were 30 years of age or older. Eighteen patients were female and 1 was a 9-year-old boy. Treatment varied from local excision of the tumor to radical mastectomy. Four of the 11 patients who had axillary node dissection had metastatic deposits showing the same secretory features as the primary neoplasm. One of these 4 patients, a 25-year-old woman, died within ten months with disseminated tumor. Because this distinctive pattern of carcinoma is not limited to children and adolescents, we propose that it be called "secretory carcinoma." Since, of the 19 patients, 4 (21%) had axillary node metastases and 1 (5%) died with disseminated tumor, an extended simple mastectomy is recommended as the initial treatment for patients more than 20 years of age.

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    • "Secretory carcinoma was first reported in children and the older literature identified the disease by the name of juvenile breast carcinoma. However, after the review by Tavassoli and Norris [3], it was recognised that it may occur in adult patients as well. Recently, the tumor was found to be associated with a distinct ETV6-NTRK3 mutation which confers the tumor proliferative and survival advantage. "
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    ABSTRACT: Secretory carcinoma of the breast is an extremely rare subtype of breast cancer characterized by intracellular or extracellular secretion and granular eosinophilic cytoplasm of the neoplastic cells. The disease which was considered to be predominant in younger age group has been recognized in adult population too and tends to show slow growth and indolent behavior. The disease occurs preferentially in females and only 27 cases have been reported amongst males. An optimal treatment for the disease subtype has been debated because of the paucity of data. We report two cases (one female and one male) of this rare disease that underwent treatment at our institution.
    01/2015; 2015:581892. DOI:10.1155/2015/581892
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    ABSTRACT: A case of secretory or juvenile carcinoma of the breast is reported in a 16 year old girl. A wide local excision was performed and no recurrence or lymph node metastases were detected at follow-up. This uncommon variety of breast tumor can also occur in adults. Most reports stress the low degree of malignancy with a slow rate of growth and a minimal risk of metastatic spread. Because of the limited number of cases reported, the initial treatment of choice is debatable. Consequently we suggest that the treatment of such a lesion should be individualized.
    Human Pathlogy 12/1981; 12(11):1044-6. DOI:10.1016/S0046-8177(81)80266-3 · 2.81 Impact Factor
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    ABSTRACT: An autopsy case is presented in which a pulmonary carcinosarcoma filled the left chest of a 61 year old man. The extensive pleural involvement that this neoplasm exhibited has not been reported previously. By light microscopy the neoplasm initially was considered a mesothelioma because of the pattern of glands and undifferentiated sarcomatous stroma. However, by electron microscopy the sarcomatous component was found to show rhabdomyoblastic differentiation. Neither histochemical stains nor electron microscopy supported a mesothelial origin for the glandular component. Differential diagnostic considerations of pleuropulmonary neoplasms showing rhabdomyosarcomatous differentiation are discussed. This case illustrates the importance of detailed study in order to characterize and properly classify these neoplasms.
    Human Pathlogy 12/1981; 12(11):1046-51. DOI:10.1016/S0046-8177(81)80267-5 · 2.81 Impact Factor
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