Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathology correlates

American Journal of Surgical Pathology (Impact Factor: 5.15). 09/1984; 8(8):625-34. DOI: 10.1097/00000478-198408000-00006
Source: PubMed


Adenocarcinoma of the rete testis is a rare tumor that tends to occur in men over the age of 60 and is usually associated with a poor prognosis. We report such a tumor occurring in a 63-year-old male 2 years after he underwent a scrotal exploration in the management of a hydrocele, varicocele, and inguinal hernia. The postorchidectomy course was characterized by slowly advancing, painful scrotal and perineal skin recurrences, lymph node metastases, and the absence of response to Adriamycin and electron-beam therapy. We are confident that the lesion is a carcinoma of the rete testis because: 1) the tumor is situated mainly in the testicular mediastinum, 2) primary germinal and nongerminal testicular tumors and spread from distant sources have been excluded, 3) a transition from normal rete testis to atypical and neoplastic rete epithelium is demonstrable, and 4) the transmission electron-microscopic findings support our conclusion. The distinction between carcinoma of the rete testis and malignant mesothelioma may be difficult and requires consideration of the gross, light-microscopic, and ultrastructural tumor characteristics in optimally fixed tissue.

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    • "No involvement of the tumor to the testicular parenchyma or tunica was detected. A diagnosis of poorly-differentiated adenocarcinoma of the rete testis was established based on the diagnostic criteria of Nochomovitz and Orenstein (1). "
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    ABSTRACT: Primary adenocarcinoma of the rete testis is an extremely rare extratesticular neoplasm. Due to its low occurrence and the scarcity of data, sonographic characteristics of adenocarcinoma of the rete testis are still poorly defined. A 46-year-old male complained of swelling and pain in the right side of the scrotum. No associated symptoms were observed. Anti-tuberculosis chemotherapy yielded no response. Postoperative pathology revealed a diagnosis of poorly-differentiated adenocarcinoma of the rete testis. Using the ultrasonography features observed, combined with a review of current literature, the diagnosis and differential diagnosis of this neoplasm are presented.
    Oncology letters 02/2014; 7(2):455-457. DOI:10.3892/ol.2013.1708 · 1.55 Impact Factor
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    • "The histologic diagnosis of this tumor is usually difficult. To date, the generally accepted histologic criteria proposed by Nochomovitz and Orenstein include the location of the tumor in the mediastinum of the testis rather than intraparenchymal, transition from normal epithelial structures to neoplastic structures in the rete testis, no evidence of teratoma, exclusion of any primary tumor of a distant site, lack of direct extension through the tunica and a predominantly solid gross appearance [3]. However, it is difficult for many tumors to meet all of the above criteria. "
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    ABSTRACT: Adenocarcinoma of the rete testis is very rare. There is still little knowledge about its etiology and pathogenesis. Herein, we present a case of rete testis adenocarcinoma in a 36-year-old Chinese male. The tumor was predominantly composed of irregular small tubules and papillary structures with cuboidal or polygonal cells. In peripheral area of the tumor, the remaining normal rete testis and adenomatous hyperplasia of the rete testis could also be seen, indicating the possible relationship between adenomatous hyperplasia and adenocarcinoma. In addition, the patient underwent a left hydrocelectomy because of the existence of hydrocele 3 years ago. But, it is unclear whether hydrocele and hydrocelectomy is its cause or just the early clinical presentation of the adenocarcinoma. Virtual slides The virtual slide(s) for this article can be found here:
    Diagnostic Pathology 06/2013; 8(1):105. DOI:10.1186/1746-1596-8-105 · 2.60 Impact Factor
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    ABSTRACT: Adenocarcinoma of the rete testis is a rare tumour with a varied presentation. A total of 44 cases have been reported [1]. Of these testicular tumours, primary nongerm cell tumours account for a minority of cases. Among this, adenocarcinoma originating in the rete testis is still rarer. It is a highly malignant tumour with poor prognosis. It is generally diagnosed clinically as a solid or cystic swelling. However, confirmation is made only on histological diagnosis.
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