Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats.

Endocrine and Polypeptide Laboratories, Veterans Administration Medical Center, and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70146, USA
Life Sciences (Impact Factor: 2.56). 07/1984; 34(26):2597-603. DOI:10.1016/0024-3205(84)90046-8
Source: PubMed

ABSTRACT The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.

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