Chronic myelogenous leukemia with a complex Ph1 translocation in an XYY male

Department of Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Cancer Genetics and Cytogenetics (Impact Factor: 1.93). 03/1984; 11(2):215-9. DOI: 10.1016/0165-4608(84)90115-8
Source: PubMed


We encountered a 38-year-old Japanese male patient with chronic myelogenous leukemia (CML), whose bone marrow and peripheral blood cells during the chronic and blastic phases contained a complex Ph1 translocation and an extra Y chromosome [i.e., 47,XYY,t(9;22;13)(q34;q11;q14)]. A karyotypic analysis of PHA-stimulated lymphocytes showed the constitutional karyotype to be 47,XYY. Thus, it was considered that CML with a complex Ph1 translocation developed in an XYY male; such a case has not been reported, so far. A B-lymphocyte cell line with the complex Ph1 translocation was established by the procedure of Epstein-Barr virus transformation. The presence of the complex Ph1 translocation in the B-lymphocyte cell line suggests that some of the B lymphocytes in this patient originated from the CML clone.

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