Article
Chromosome studies in 496 infertile males with a sperm count below 10 million/ml.
University of Stellenbosch
Human Genetics (impact factor:
5.07).
02/1984;
66(2-3):162-4.
DOI:10.1007/BF00286592
pp.162-4
Source: PubMed
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Citations (0)
- Cited In (4)
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Article: Microdeletions on the long arm of the Y chromosome and their association with male-factor infertility.
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ABSTRACT: Significant advances in treatment have enabled previously infertile males to achieve fatherhood, when only a few years ago they would have had no chance of biological paternity. In contrast to the overall success of assisted reproduction, the aetiology of male-factor infertility is poorly understood. Recent studies have shown, however, that a significant proportion of men with severe infertility have microdeletions of the Y chromosome. Furthermore, reports have shown that male infants conceived through assisted reproductive techniques have inherited the same Y-chromosome microdeletion as their fathers. It has thus become important to screen men who are at risk of Y-chromosome microdeletions, as this will determine if counselling is needed prior to starting infertility treatment. This review examines the significance and limitations of the current understanding of Y-chromosome microdeletions in male infertility.Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 07/2000; 6(2):184-9. -
Article: Twenty-six-year-old primigravid woman with a cystic mass.
Reviews in urology 02/2005; 7(1):58-62. -
Article: Chromosome studies in patients with defective reproductive success.
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ABSTRACT: The objective of this study was to evaluate the contribution of chromosomal anomalies to decreased fertility in humans. In order to investigate the aetiology of infertility in our population and to assess the karyotype in a group of infertile couples and individuals with fertility problems, 782 persons (259 couples, 158 male and 106 female) with different clinical diagnoses of sterility and infertility were analysed cytogenetically. The overall frequency of major chromosomal aberration was 13.1% (103/783), which suggests that fertility or sterility problems in this population are due to chromosomal aberrations. Couples experiencing repeated spontaneous abortions, having malformed children or having sterility problems had chromosomal abnormalities in 18.0% (47/259 couples) of the population studied, and constituted chromosomal disorders occured in couples seeking IVF and ICSI with prevalence of 22.2% (8/38 couples), especially minor mosaicism of sex chromosomes in the female partners. The prevalence of chromosome abnormalities in infertile men was 17.7% (28/158), and in subfertile females, it was 26.4% (28/106). These results could indicate an increased tendency to miotic sex chromosome non-disjuction in humans.American journal of reproductive immunology (New York, N.Y.: 1989) 12/2000; 44(5):279-83. · 3.05 Impact Factor
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Keywords
7.1% constitutional abnormalities
azoospermia
azoospermia group
chromosome abnormalities
Chromosome studies
consistent sperm count
Constitutional chromosome abnormalities
infertile men
normal population
oligozoospermia
oligozoospermia group
routine chromosome analysis
workload increases