Based on the limited results of this eight-week comparison of formocresol and glutaraldehyde, it would appear that glutaraldehyde may offer distinct advantages over formocresol, in the treatment of cariously exposed primary and young permanent teeth. In particular, due to its chemical structure, it is more active in fixing the surface tissues and is more rapidly limited in its depth of penetration through these tissues. Glutaraldehyde does not exhibit as significant an ability to induce the total loss of vitality, in the radicular pulp tissues. The progression of formocresol treated pulps to apparent fibrotic replacement via granulation-tissue ingrowth, through the apex, does not occur with the glutaraldehyde-treated pulp tissues. There may, however, be a slow progression of fibrotic replacement of the glutaraldehyde fixed tissue, in the coronal portion of the radicular pulp. Perhaps most importantly it would seem that since the glutaraldehyde does not perfuse the tissues to the apex, it will not demonstrate systemic distribution and other extradental phenomena, as have been identified with the use of formocresol
"In 1976, Dankert, s’Gravenmade and Wemes reported
the advantages of glutaraldehyde as an intracanal medicament
during endodontic therapy.5 Ample evidence has
accumulated overtime, which has led investigators to suggest
that glutaraldehyde should replace formocresol as the
medicament of choice for chemical pulpotomy procedures
on primary teeth. Numerous studies have shown that
application of 2 to 5% aqueous glutaraldehyde produces
surface fixation of the underlying pulpal tissue with limited
depth of penetration.6-9 Glutaraldehyde has more stable
interactions with proteins rather than formocresol, as it has
two functional aldehyde groups and this accounts for its
powerful bactericidal activity.7 "
[Show abstract][Hide abstract] ABSTRACT: Purpose:
To evaluate and compare clinically and radiographically use of hydroxyapatite crystals and 2% glutaraldehyde as a pulpotomy agent.
Thirty deciduous molars were treated with pulpotomy using hydroxyapatite crystals and 2% glutaraldehyde.
Clinical and radiographic findings were observed at three months and six months. The success rate was found to be 100% clinically and 80.33% radiographically in the hydroxyapatite crystals group and 100% clinically and radiographically in the glutaraldehyde group.
The results of this study revealed that hydroxyapatite crystals is a potential pulpotomy agent for deciduous molars.
[Show abstract][Hide abstract] ABSTRACT: Two bifunctional reagents, glutaraldehyde and dimethylsuberimidate, were compared to formaldehyde with respect to fixation and modification of protein. Glutaraldehyde proved the superior fixative based on cross-linking and enzyme degradation assays. An immunoprecipitation assay suggests that the reaction products of glutaraldehyde may have altered antigenicity.
Journal of Dental Research 11/1983; 62(10):1054-7. DOI:10.1177/00220345830620100901 · 4.14 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.