Regulation of the macrophage content of neoplasms by chemoattractants.

University of Milan, Milano, Lombardy, Italy
Science (Impact Factor: 31.48). 05/1983; 220(4593):210-2. DOI: 10.1126/science.6828888
Source: PubMed

ABSTRACT Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.

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