Effects of lasalocid or monensin on legume or grain (feedlot) bloat.

Journal of Animal Science (Impact Factor: 1.92). 07/1983; 56(6):1400-6.
Source: PubMed

ABSTRACT Doses of .66 to .99 mg monensin/kg body weight reduced legume bloat in cattle about 66% when compared with pretreatment bloat scores. Similar doses of lasalocid reduced legume bloat about 26%. A dose of 44 mg poloxalene/kg body weight (recommended dose for field use) reduced legume bloat 100%. Monensin or lasalocid combined with 25 or 50% of the recommended dose of poloxalene reduced bloat under that of the antibiotics alone, but did not achieve 100% reduction. The antibiotic thiopeptin provided no preventive effect on legume bloat. Lasalocid, monensin or an experimental polyether antibiotic (X-14,547 A) at a dose of 1.32 mg/kg body weight when tested on cattle bloated on high grain diets reduced bloat by 92, 64 and 25%, respectively. Lasalocid at .66 mg/kg effectively prevented bloat from developing when given to animals before the feeding of high grain diets; however, a 1.32-mg dose was required to control bloat in cattle that were already bloating before they were given lasalocid. A dose of 1.32 mg salinomycin was ineffective in controlling grain bloat.

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    ABSTRACT: Ionophores are used commercially throughout the world in the beef and poultry industries. Production efficiency of cattle is increased through alteration of rumen fermentation and control of protozoa that cause coccidiosis. Ionophores act by interrupting transmembrane movement and intracellular equilibrium of ions in certain classes of bacteria and protozoa that inhabit the gastrointestinal tract. The actions of iono- phores provide a competitive advantage for certain microbes at the expense of others. In general, the metabolism of the selected microorganisms favors the host animal. Energy me- tabolism is enhanced through increased production of propio- nate among ruminal fatty acids with a concomitant reduction in methane. Ruminal degradation of peptides and amino acids is reduced, thereby increasing the flow of protein of dietary origin to the small intestine. Total flow of protein to the lower tract is often increased with ionophore feeding. Risk of diges- tive disorders such as bloat and acidosis that result from ab- normal rumen fermentation is reduced, as are certain condi- tions caused by toxic products of fermentation, e.g., 3-methyl indole. Dry matter and nitrogen digestibilities are increased with ionophores, thereby providing environmental benefits. Monensin and lasalocid have been the most studied in research demonstrating benefits to the dairy cow. Ionophores enhance the glucose status of dairy cows through increased production of propionate. Many of the demonstrated benefits of ionopho- res are associated with enhancement of the energy status of the cow in the transition period and during early lactation. The benefits include less mobilization of body fat as evidenced by reduced blood nonesterified fatty acids and ketones and in- creased glucose. Animal manifestations include lower inci- dence of ketosis and displaced abomasum, reduced loss of body condition, increased milk production, and improved milk production efficiency.
    Journal of Dairy Science 06/2001; 84. DOI:10.3168/jds.S0022-0302(01)70218-4 · 2.55 Impact Factor
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    Nutritional Strategies of Animal Feed Additives, 01/2013: pages 115-120; Nova Science Publishers, Hauppauge, NY, USA., ISBN: 978-1-62417-000-3
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