Thoracic and abdominal radiographic abnormalities in the multicentric form of lymphosarcoma in dogs.
ABSTRACT Thoracic and abdominal radiographs from 100 dogs with lymphosarcoma were reviewed to determine the type and frequency of radiographic abnormalities associated with the disease. Sternal lymphadenopathy was the most frequent (60%) thoracic radiographic abnormality. Hepatomegaly (47%), splenomegaly (55%), and sublumbar lymphadenopathy (49.5%) were the most frequent abdominal radiographic abnormalities; these were most often seen in combination. A single radiographic abnormality or combination of abnormalities was not observed frequently enough to suggest that a diagnosis could be made only on the basis of radiographic findings.
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ABSTRACT: A lumbar extradural lymphoma compressing the spinal cord was identified on contrast enhanced computed tomography (CT) and magnetic resonance imaging (MRI) images in a 4-year-old Bordeaux dog presented with posterior paresis. A significant paravertebral extension was only clearly defined on contrast MRI images; therefore, MRI was more useful than CT in imaging of spinal extradural lymphoma in this dog.The Canadian veterinary journal. La revue veterinaire canadienne 05/2010; 51(5):519-21. · 0.77 Impact Factor
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ABSTRACT: Multicentric lymphoma (grade V) was diagnosed in a 7-year-old dog with listlessness, excessive panting and generalized lymphadenopathy. Hematological examination showed reduced RBC and platelet count and severe increase in leukocyte count with 90% of lymphocytes and 10% of neutrophils. Radiographic examination showed soft tissue masses (sublumbar lymph nodes) in caudal abdomen and mild liver enlargement. Prostate gland and spleen were also enlarged. There were no other abnormalities in abdominal and thoracic radiography, and metastatic mass couldn’t be found in the lungs. Histopathological examination of the right popliteal lymph node showed large neoplastic lymphoblasts, and the immunophenotype of the tumor showed B-cell origin with CD3 and CD20 expression. Treatment with systemic chemotherapy was initiated in an attempt to induce remission using cyclophosphamide, vincristine, and prednisolon (COP) in doses recommended in the literature. Currently, the patient is clinically doing very well with a good appetite, adequate weight gain, increased activity level, decreased lymph node size, and return to normal attitude. KeywordsMulticentric lymphoma–Dog–Immunophenotype–ChemotherapyComparative Clinical Pathology 01/2011; 20(3):273-275.
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ABSTRACT: Seven dogs with pulmonary lymphomatoid granulomatosis were reviewed. The disease occurred in six large-breed and one small-breed dogs. The dogs were five to 14 years old (mean, 8.4; median, 7), and four of seven dogs were males. Three dogs had been previously treated with adulticide therapy for canine dirofilariasis. Clinical histories included a progressive respiratory disease characterized by varying degrees of cough, dyspnea, exercise intolerance, and weight loss. Thoracic radiographic features included hilar lymphadenopathy, pulmonary masses of varying sizes, and mixed pulmonary patterns of lobar consolidation with ill-defined interstitial and alveolar pulmonary infiltrates. Cardiovascular changes compatible with chronic dirofilariasis were present in three dogs. The clinical course was usually progressive and fatal. The survival time ranged from six days to four years (mean, 12.5 mos; median, 3 mos). Gross and histologic features included mass lesions with areas of necrosis that replaced normal pulmonary architecture. Cytologically, these lesions were characterized by infiltration with pleomorphic, angioinvasive mononuclear cells that often resulted in vascular obliteration. The infiltrating cells resembled large lymphoid cells that possessed large hyperchromatic nuclei and small amounts of cytoplasm. Systemic lymphoid neoplasia with peripheral lymphadenopathy was diagnosed in two dogs. In both cases, lymph-node cytology was similar to the cellular infiltrates found in the lungs and consistent with a diagnosis of lymphomatoid granulomatosis. These features are compared with previously reported cases of canine lymphomatoid granulomatosis and those features identified in a similar disease described in man.Journal of Veterinary Internal Medicine 01/1990; 4(3):157-66. · 2.06 Impact Factor