Human hypospermatogenesis. Histopathology and ultrastructure.
ABSTRACT Testicular biopsy specimens from 25 patients with hypospermatogenesis were studied with both light and electron microscopy. In five cases, the condition was found in only one testis. In hypospermatogenesis, the number of the spermatogenic cells was reduced by about half, although there was considerable variation in different cases. The numbers of all types of germ cells (spermatogonia, spermatocytes, and spermatids) were reduced, but few degenerative cells were seen. This indicates that the primary defect in hypospermatogenesis is in the stem cell population, which is somehow inhibited from entering the line of germ cell differentiation, but that once the cells are committed to this line of differentiation spermatogenesis proceeds normally.
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ABSTRACT: The correlations between the progression of germ-cell hypoplasia, measured with the Johnsen's score, reduction in tubular diameter, and thickening of the lamina propria of the seminiferous tubules were studied in a series of 42 biopsy specimens of the testis from 26 infertile men. There was a significant negative correlation between the mean tubular diameter and the mean thickness of the lamina propria (p less than 0.01), as well as a significant positive correlation between the Johnsen's score and the mean tubular diameter (p less than 0.01). The Johnsen's score did not correlate with the mean thickness of the lamina propria. Reduction of the tubular diameter and thickening of the lamina propria could be found across the spectrum of scores, but they prevailed in severe germ-cell hypoplasia.Archives of Andrology 02/1987; 19(1):1-4. DOI:10.3109/01485018708986794 · 0.89 Impact Factor