The prevalence of polyps of the large intestine in Oslo: An autopsy study

Cancer (Impact Factor: 4.9). 03/1982; 49(4):819-25. DOI: 10.1002/1097-0142(19820215)49:43.0.CO;2-D
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ABSTRACT The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no histologic diagnosis could be made. Adenomas were present in 34% of the men and 32% of the women. The adenoma prevalence rate increased smoothly with age in men, whereas the rate in women showed a biphasic variation with a peak at 50--59 years followed by a second increase after 70 years of age. The distribution of adenomas within the bowel showed a marked change with age, from a moderate left-sided predominance before 60 years of age to a marked right-sided predominance in patients over 80 years of age, particularly in men. Hyperplastic polyps were present in 27% of the men and 18% of the women. In men, their frequency and distribution within the bowel showed similar changes with age as were seen for the adenomas. In women, no such age-dependency was observed for hyperplastic polyps. Multiplicity of polyps increased with age and was more pronounced in men than in women. Adenomas in women tended to be larger, more atypical, and more villous than in men. A comparison with a similar study from Northern Norway showed no difference in the prevalence of adenomas in spite of a 70% higher incidence rate for colorectal cancer in Oslo.

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Available from: Morten H Vatn, Sep 24, 2014
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    • "Prevalence numbers in the general population vary in different studies. In individuals over the age of 50 years the prevalence of hyperplastic polyps has been determined to be 20–40% [41] [43]. Few reports present the prevalence of hyperplastic polyps in HNPCC. "
    Disease markers 02/2004; 20(4-5):259-67. DOI:10.1155/2004/246585 · 2.17 Impact Factor
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    • "Adenomas are a common ®nding in the colon, and the prevalence increases with age [Vatn and Stalsberg, 1982; Rex et al., 1993]. Sixty to ninety percent of the colorectal cancers (CRC) are believed to develop from adenomas [Morson, 1974; Vogelstein et al., 1988; Atkin et al., 1992]. "
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    ABSTRACT: Most studies demonstrate increased risk of colorectal cancer (CRC) and adenomas in folate-deficient subjects or that high folate intake may afford some protection. Smoking increases such risk in some but not all studies. We investigated whether smoking, folate status and methylenetetrahydrofolate reductase (MTHFR) genotype predict the risk of adenomatous and hyperplastic polyps of colorectum. By colonoscopy, the type, number, size and extent of dysplasia of colorectal polyps were assessed in 443 subjects aged 63-72 years. We also determined RBC folate and the C667T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Smoking, folate status and the C677T MTHFR polymorphism were strong, interactive determinants of high-risk adenomas (HRAs, defined as adenomas > or =10 mm in diameter, adenomas with villous components or with severe dysplasia). The risk was particularly high in smokers with low folate and the CT/TT genotype (risk category T) and in smokers with high folate and the CC genotype (risk category C). With non-smokers with low folate and the CC genotype as reference, the odds ratios (OR, 95% CI) were 8.7 (2.5-29.7) in category T and 9.9 (2.6-38.4) in category C. Notably, this risk pattern was also observed for hyperplastic polyps. In conclusion, in smokers, high folate status may confer increased or decreased risk for HRAs, depending on the MTHFR genotype. These data demonstrate the strong gene-nutrition interaction involving the C677T MTHFR polymorphism.
    American Journal of Medical Genetics 07/2001; 101(3):246-54. DOI:10.1002/ajmg.1370 · 3.23 Impact Factor
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    • "Distal cancers are suggested to be more related to environmental factors and proximal cancers more genetically caused (Bonithon-Kopp et al., 1999). There seems to be increasing prevalence of proximal cancers with increasing age (Eide et al., 1978; Thiis-Evensen et al., 1999; Vatn et al., 1982). "
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