A new look at adult asthma.
ABSTRACT Understanding of the natural history of asthma is hampered by the lack of precise definitions. A new definition of severe acute asthma is proposed with primary emphasis on the circulatory disturbances. The natural history of severe acute asthma and the value of steroid therapy are re-examined in the light of the new definition.
Article: The case for steroids.Intensive Care Medicine 02/1984; 10(3):113-4. · 5.54 Impact Factor
Article: Status asthmaticus in adults[Show abstract] [Hide abstract]
ABSTRACT: Status asthmaticus is a severe, life-threatening exacerbation of bronchial asthma that fails to improve with "conventional" treatment. "Conventional" treatment has been defined as three subcutaneous injections of epinephrine given at 15-min intervals. The use of the term "status asthmaticus" has value in that it has simplified communication. However, it has the disadvantages that it is too restrictive. It draws attention away from other aspects of severe asthma; for example, that patients die at home L2 and, in some cases, within minutes of the onset of an attack/'3 It is probably more useful to talk of "severe acute asthma," rather than "status asthmaticus. "4 Between 1959 and 1979, the overall mortality due to asthma in patients from 5 to 34 years of age ranged from 0.2 to 4.1 deaths per 100,000 persons. In the United States and Canada, mortality was fairly constant, being between 0.2 and 0.4 deaths per 100,000 persons, s The hospital mortality for severe acute asthma in adult patients is shown in Table 1. The mean mortality is 1.34%. Asthma remains a potentially lethal disease, and its mortality has not declined significantly over the last 20 years.Clinical Reviews in Allergy & Immunology 3(1):69-94. · 5.59 Impact Factor
- Clinical Reviews in Allergy 04/1983; 1(1):123-46.