Altered adult behavior of mice following postnatal treatment with haloperidol

University of Rochester, Rochester, New York, United States
Pharmacology Biochemistry and Behavior (Impact Factor: 2.78). 06/1982; 16(5):761-7. DOI: 10.1016/0091-3057(82)90232-5
Source: PubMed


Haloperidol (1 and 2 mg/kg) was administered SC daily to BALB/c and Swiss/Webster mice from postnatal days 4 through 21. Non consistent statistically significant drug effects were detected on growth and reflex development. Spontaneous motor activity increased significantly in both sexes of the Swiss/Webster outbred strain, and in the Balb/c males. Performance of a fixed ratio schedule of reinforcement of both male and female haloperidol-exposed mice was not statistically different from control performance. Interpretation of such data must take into account the sensitivity of the testing devices, the effects of repeated testing of a single animal, and the suitability of traditional statistical methods in developmental pharmacology and toxicology.

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