Article

Transformation of ultrastructural type of fast-twitch muscle fibres after cross-innervation by tetrodotoxin-blocked slow muscle nerve.

Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences / Chung-kuo k'o hsüeh yüan, chu pan 10/1982; 25(9):953-60. pp.953-60
Source: PubMed

ABSTRACT It is shown in rats that cross-innervation of the fast-twitch muscle extensor digitorum longus (EDL) by the nerve of the slow-twitch muscle soleus (SOL) can cause a complete transformation of the Z-band width from the fast to the slow muscle fibre type within two weeks and that it can still induce such a transformation, though usually less completely, even when impulse activity is excluded by chronical tetrodotoxin (TTX) block of the nerve. This provides a piece of clear-cut evidence for the presence of some activity-independent trophic factor in the neural determination of skeletal muscle fibre type.

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Keywords

activity-independent trophic factor
 
chronical tetrodotoxin
 
clear-cut evidence
 
cross-innervation
 
EDL
 
fast-twitch muscle extensor digitorum longus
 
impulse activity
 
neural determination
 
skeletal muscle fibre type
 
slow muscle fibre type
 
slow-twitch muscle soleus
 
SOL
 
Z-band width