Role of aminoacylation of histidyl-tRNA in the regulation of protein degradation in Chinese hamster ovary cells.

Journal of Biological Chemistry (Impact Factor: 4.6). 08/1980; 255(13):6322-9.
Source: PubMed


Available from: James S Malter, Apr 18, 2015
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    ABSTRACT: The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.
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