Molecular biology of temporomandibular joint disorders: proposed mechanisms of disease.

Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at San Antonio 78284-7823, USA.
Journal of Oral and Maxillofacial Surgery (Impact Factor: 1.28). 01/1996; 53(12):1448-54. DOI: 10.1016/0278-2391(95)90675-4
Source: PubMed

ABSTRACT PURPOSE: The biologic processes of temporomandibular joint adaptation and disease are poorly understood. However, recent technologic advances have provided methods that allow sophisticated studies of the molecular mechanisms that are relevant to the pathophysiology of degenerative temporomandibular joint diseases. This review examines current models of the molecular events that may underlie both adaptive and pathologic responses of the articular tissues of the temporomandibular joint to mechanical stress. It is hoped that an increased understanding of these complex biologic processes will lead to improved diagnostic and therapeutic approaches directed to the management of temporomandibular disorders.

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