Molecular biology of temporomandibular joint disorders: proposed mechanisms of disease.

Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at San Antonio 78284-7823, USA.
Journal of Oral and Maxillofacial Surgery (Impact Factor: 1.28). 01/1996; 53(12):1448-54. DOI: 10.1016/0278-2391(95)90675-4
Source: PubMed

ABSTRACT PURPOSE: The biologic processes of temporomandibular joint adaptation and disease are poorly understood. However, recent technologic advances have provided methods that allow sophisticated studies of the molecular mechanisms that are relevant to the pathophysiology of degenerative temporomandibular joint diseases. This review examines current models of the molecular events that may underlie both adaptive and pathologic responses of the articular tissues of the temporomandibular joint to mechanical stress. It is hoped that an increased understanding of these complex biologic processes will lead to improved diagnostic and therapeutic approaches directed to the management of temporomandibular disorders.

  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Temporomandibular joint (TMJ) 'closed lock' (CL) is a clinical condition causing TMJ pain and limited mouth opening (painful locking) that is mostly attributed to disc displacement without reduction (DDwoR), or less commonly to anchored disc phenomenon (ADP). Both conditions are described clinically as CL that can be 'acute' or 'chronic' depending on the duration of locking. There is, however, no consensus about the duration of locking that defines the acute state and its effect on the success of interventions. This review paper, therefore, aims to provide: (i) a narrative review of the pathophysiological need for early intervention in DDwoR and the clinical implications of acute/chronic CL stages on the management pathway; (ii) a systematic review investigating the effects of locking duration on the success of interventions for CL management. Electronic and manual searches until mid-August 2013 were conducted for English-language studies of any design investigating the effects of non-surgical and surgical interventions for acute or chronic CL (DDwoR or ADP). A total of 626 records were identified, and 113 studies were included. Data extraction and quality assessment were completed for all included studies. Included studies were, however, heterogeneous and mostly of poor-quality leading to contradictory and inconsistent evidence on the effect of the duration of locking on treatment outcomes. Future high-quality trials investigating the effect of CL duration on treatment outcome are needed. At present, early intervention by 'unlock' mandibular manipulation seems to be the most practical and realistic approach that can be attempted first in every CL patient as an initial diagnostic/therapeutic approach.
    Journal of Oral Rehabilitation 01/2014; 41(1). DOI:10.1111/joor.12126 · 1.93 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective This study aimed to evaluate effects of different registration positions on the condyle-disk position changes in the mandibular fossa in symptomatic individuals. Study Design Vertical and sagittal condyle position and thickness of the bilaminar zone were measured by magnetic resonance imaging during maximal intercuspation (MI) and with jigs in Gothic arch tracing guided centric relation (DIR method [Dynamics and Intraoral Registration]) and retruded contact position (RCP). Participants were 26 patients seeking treatment for temporomandibular disorders. Condyle and disk position in the fossa were calculated in the parasagittal plane. Results Significant differences were found for MI, DIR, and RCP for thickness of bilaminar zone and sagittal condyle position, dependent on diagnosis and registration position for vertical and sagittal condyle position and thickness of bilaminar zone. Conclusions DIR position ensures the widest posterior space for the retrodiskal tissues and the slightest sagittal difference between condyle zenith and glenoid fossa.
    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 03/2014; 117(3):312–318. DOI:10.1016/j.oooo.2013.11.498 · 1.46 Impact Factor