Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.

Department of Infectious Diseases and Virology, St. Jude's Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.
Journal of Virology (Impact Factor: 5.08). 01/1996; 69(12):8155-8.
Source: PubMed

ABSTRACT In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.

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