Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. J Ethnopharmacol

Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Journal of Ethnopharmacology (Impact Factor: 3). 08/1995; 47(2):69-74. DOI: 10.1016/0378-8741(95)01254-B
Source: PubMed

ABSTRACT The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated. The increased serum enzyme levels (viz., glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase) by CCl4-induction were significantly lowered due to pretreatment with the extract. The extract also decreased the elevated serum bilirubin and urea content due to CCl4 administration. Increased activities of hepatic 5'-nucleotidase, acid phosphatase, acid ribonuclease and decreased levels of succinic dehydrogenase, glucose-6-phosphatase and cytochrome P-450 produced by CCl4 were reversed by the extract in a dose-responsive way. Results of this study revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.

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    • "Moreover, rosemary provide protection against hepatotoxins by enhancing the functioning of the hepatic antioxidant defense system (Ip and Ko, 1996), inhibiting biosynthesis of cytochrome p 450 (Rao and Misra, 1998) and preventing LPO (Malo et al., 2011). Additionally, rosemary can help in stabilizing hepatocellular membrane, enhancing protein biosynthesis (Lin et al., 1999), decreasing the leakage of marker enzymes into the circulation, interfering with the microsomal activation of PAHs and/or accelerating detoxification (Bishayee et al., 1995). In agreement with the present study, Guti errez et al. (2009) and Sotelo-Felix et al. (2002) suggested that R. officinalis therapy, acting as an antioxidant and/or a free radical scavenger, can preserve cellular integrity and counteract the severe damage induced by carbon tetrachloride (CCl 4 ). "
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    ABSTRACT: Coal tar is a significant product generated from coal pyrolysis. Coal tar can be utilized as raw materials for various industries. It is also a type of raw material from which phenols, naphthalenes, and anthracene can be extracted. The present study was designed to investigate the possibility of coal tar creosote to induce oxidative stress and biochemical perturbations in rat liver and the role of rosemary (Rosmarinus officinalis) in ameliorating its toxic effects. Male Wister Albino rats were randomly divided into four groups of seven each, group I served as control; group II treated with rosemary (10 mL of water extract/kg BW for 21 days), group III received coal tar creosote (200 mg/4 mL olive oil/kg BW for 3 days), and group IV treated with both rosemary and coal tar creosote. The administration of coal tar creosote significantly caused elevation in lipid peroxidation (LPO) and reduction in the activities of glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). A significant decrease in reduced glutathione (GSH) content was also observed. Liver aminotransferases aspartate transaminase (AST) and alanine transaminase (ALT)] and alkaline phosphatase (AlP) were significantly decreased while lactate dehydrogenase (LDH) was increased. Rosemary pretreatment to coal tar creosote-treated rats decreased LPO level and normalized GPx, GR, SOD, CAT, and GST activities, while GSH content was increased. Also, liver AST, ALT, AlP, and LDH were maintained near normal level due to rosemary treatment. In conclusion, rosemary has beneficial effects and could be able to antagonize coal tar creosote toxicity. © 2014 Wiley Periodicals, Inc. Environ Toxicol, 2014.
    Environmental Toxicology 07/2014; DOI:10.1002/tox.22024 · 3.23 Impact Factor
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    • "The antioxidative properties of some vegetables and fruits are partly due to the low molecular weight phenolic compounds, which are known to be potent as antioxidants (Wang et al., 1999). Daucus is used as antibacterial, stimulant (Emilio, 1994), antiseptic, carminative, diuretic, hepatoprotective (Bishayee et al., 1995), antisteroidogenic (Majumder et al., 1997) and anti-inflammatory (Porchezhian et al., 2000). The substances in carrots have a diuretic effect; help to ease an irritated gastrointestinal system, and help resistance to cancer (Radulovicét al., 2011).A great number of species and sub-species of Daucus genus have been tested for their antioxidant and antimicrobial activities during the last decade; however, there are still many others species of Daucus, which were not yet examined. "
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    ABSTRACT: The present study was to estimate preliminary photochemical evaluation and in vitro antioxidant of aerial parts extracts of Daucus aureus by using both solvents like ethanol and water. Preliminary phytochemical analysis reveals the presence of tannins, flavanoids, steroids and terpenoids. The extracts were screened for its potential antioxidant activity using DPPH free radical scavenging activity. The reducing power extract was also determined ascorbic acid was used as a standard and positive control for aerial parts analysis. Ethanol extract showed significant activity with DPPH (2, 2-Diphenyl-1-picryl-hydrazyl) radical scavenging compared to standard antioxidant. However, increasing the concentration of the extracts resulted in increased ferric reducing antioxidant power for both extracts tested. From the analyses, ethanolic extract had the highest total phenolic content. Finally, a relationship was observed between the antioxidant activity potential and total phenolic and flavonoid levels of the extract. The results were concluded that extracts have a potential source of antioxidants of natural origin.
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    • "In the traditional system of medicine Daucus carota plant has been used as a diuretic and inotropic, cystitis, gout and lithuria [13] [14] . Scientific studies have shown that extract obtained from various parts of the Daucus carota plant possesses analgesic and anti-inflammatory [15] , hepatoprotective [16] , hypoglycemic [17] , antiulcer [18] , antifertility [19] , anticancer [20] , anti-tumor [21] . "
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    ABSTRACT: Objective Daucus carota L. (Carrot) (Apiaceae) is used in the traditional medicine for the treatment of variety of ailments. The aim of present investigation was to formulate and evaluate wound healing activity of ethanolic extract of Daucus carota L. root on excision wound model and incision wound model.Methods The soft paraffin based cream containing 1%, 2% and 4% w/w of ethanolic extract of Daucus carota L. (EEDC) root was formulated and evaluated for pharmaceutical parameters such as rheological properties, pH, skin irritation and external characters. Excision wounds sized 300 mm2 and 2 mm depth were used for the study of rate of contraction of wound and epithelization at different time intervals. Incision wounds six centimeter long and two linear-paravertebral incisions were used for the study of tensile strength, total protein and hydroxyproline content measured on 10th day old incision wound.ResultsEthanolic extract of Daucus carota L. root cream formulation when applied topically did not show any sign and symptoms of skin irritation. Animals treated with topical EEDC cream formulation (1%, 2% and 4% w/w) showed significance decrease in wound area, epithelization period and scar width whereas rate of wound contraction significantly increased (P <0.01, P <0.001 and P <0.001 resp.) as compared to control group animals in excision wound model. In incision wound model there was significant increase (P <0.01 and P <0.001) in tensile strength, hydroxyproline content and protein content of animals treated with topical EEDC cream formulation (2% and 4% w/w, respectively).Conclusions Wound-healing property of ethanolic extract of Daucus carota L. root may be attributed to the various phytoconstituents like flavonoids and phenolic derivatives present in the root and the quicker process of wound healing could be a function of either its antioxidant or antimicrobial potential. The present findings provide scientific evidence to the ethanomedicinal properties of Daucus carota in wounds healing activity.
    Asian Pacific Journal of Tropical Biomedicine 02/2012; 2(2). DOI:10.1016/S2221-1691(12)60290-1
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