Article

Bone marrow angiogenesis and progression in multiple myeloma.

Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy.
British Journal of Haematology (impact factor: 4.94). 08/1994; 87(3):503-8.
Source: PubMed

ABSTRACT Tumour growth is angiogenesis-dependent. We found a high correlation between the extent of bone marrow angiogenesis, evaluated as microvessel area, and the proliferating (S-phase) fraction of marrow plasma cells, evaluated as labelling index (LI), in patients with multiple myeloma (MM) and in those with monoclonal gammopathies of undetermined significance (MGUS). Angiogenesis itself was significantly associated with active as opposed to non-active MM and MGUS. The highest microvessel area accompanied rapidly progressive MM with the highest LI. When a cut-off value of 2% or greater of the microvessel area was used, most patients with active MM were classified correctly. The risk of active disease in patients with MM increased in parallel with the microvessel area. A causal relationship between plasma cell growth, activity phase in MM and marrow angiogenesis is suggested. Since angiogenesis proceeds in step with the enlargement of plasma cell tumours and the activity phase in MM, its measurement could be a useful prognostic marker in patients with plasma cell proliferative disorders.

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Keywords

activity phase
 
Angiogenesis
 
angiogenesis proceeds
 
bone marrow angiogenesis
 
enlargement
 
highest LI
 
highest microvessel area
 
labelling index
 
marrow angiogenesis
 
marrow plasma cells
 
MGUS
 
microvessel area
 
monoclonal gammopathies
 
multiple myeloma
 
plasma cell growth
 
plasma cell proliferative disorders
 
plasma cell tumours
 
proliferating
 
Tumour growth
 
useful prognostic marker