Viral dynamics in human immunodeficiency virus type 1 infection.
ABSTRACT The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life approximately 2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.
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ABSTRACT: The emerging drug resistance towards anti-HIV compounds attracted the attention of scientific community. Development of potent anti-HIV therapy using non-nucleoside reverse transcriptase inhibitors (NNRTIs) known to be a promising strategy. Although NNRTIs has great importance in HIV-1 treatment and prevention but their mechanism of action has not yet been studied in detail. The present review discusses cellular interactions of HIV-1 followed by the FDA approved anti-HIV-1 chemotherapy. The review highlights the importance of NNRTIs and their mechanism of action in HIV-1 treatment. Also the current challenges and future prospective of NNRTIs to prevent HIV-1infection are well addressed so as to propose the development of novel therapeutic strategies for its treatment.
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ABSTRACT: Based on heterogeneities in drug efficacy (either spatial or phenotypic), two HIV compartmental models were proposed in Callaway and Perelson (2002) to study the HIV virus dynamics under drug treatment. In this paper, we provide a global analysis on the two models, including the positivity and boundedness of solutions and the global stability of equilibrium solutions. In particular, we show that when the basic reproduction number (for which the infection equilibrium does not exist), the infection-free equilibrium is globally asymptotically stable; while when (for which the infection equilibrium exists), the infection equilibrium is globally asymptotically stable.Communications in Nonlinear Science and Numerical Simulation 06/2015; DOI:10.1016/j.cnsns.2014.11.001 · 2.57 Impact Factor
Journal of Experimental Medicine 01/2001; 194(12):1731-1741. DOI:10.1084/jem.194.12.1731 · 13.91 Impact Factor