Article
Propionibacterium acnes endocarditis.
Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada.
The Canadian journal of cardiology (impact factor:
3.36).
11/1995;
11(9):785-7.
pp.785-7
Source: PubMed
-
Citations (0)
- Cited In (2)
-
Article: Endocarditis crónica sobre válvula protésica por Propionibacterium acnes: una causa insospechada de disfunción protésica
[show abstract] [hide abstract]
ABSTRACT: Recibido el 12 de febrero de 2008. Aceptado para su publicación el 6 de noviembre de 2008. introducción y objetivos. Describir las características de la endocarditis infecciosa sobre válvula protésica por Propionibacterium acnes (EIVPPA) Métodos. Descripción prospectiva y consecutiva de 16 casos de EIVPPA. resultados. Siete pacientes presentaron EIVPPA pre-coz y 9 tardías. Las tardías siempre tenían el anteceden-te de algún tipo de manipulación de la barrera mucocu-tánea. El retraso diagnóstico fue > 3 meses en el 75%. La presentación clínica fue fundamentalmente disfun-ción protésica asintomática (31%), insuficiencia cardiaca (19%), síndrome coronario (12,5%), fiebre (25%) y défi-cits neurológicos (19%). Al ingreso diagnóstico el 62,5% presentaba insuficiencia cardiaca y el 44% fiebre. Eco-cardiográficamente, predominó la disfunción protésica por dehiscencia en las metálicas aórticas (6 de 7), o por estenosis en las metálicas mitrales (4 de 7). Las biológi-cas presentaron disfunción por distorsión de velos (2 de 3). Los cultivos de sangre y muestras quirúrgicas fueron positivos tras 11,6 y 12,2 días de media respectivamente. En 2 casos la PCR confirmó el diagnóstico. El hallazgo intraoperatorio principal fue la presencia de abundante pannus grisáceo. La histología mostró ausencia de datos de actividad aguda. Doce pacientes recibieron antibio-terapia más recambio valvular, 7 curaron, 4 presentaron dehiscencia precoz y 1, recaída; 3 pacientes fueron ini-cialmente tratados sólo con antibióticos, y los 3 recaye-ron. conclusiones. La EIVPPA se presenta generalmente con disfunción valvular y escasos síntomas infecciosos. Es imprescindible la larga incubación de los cultivos para su diagnóstico. La antibioterapia controla la clínica, pero no elimina la infección, y es necesaria la sustitución valvular para la curación. La evolución posquirúrgica puede verse complicada por la presencia de dehiscencia protésica. Palabras clave: Endocarditis protésica. Propionibacte-rium acnes. Biocapa. chronic Prosthetic Valve Endocarditis Due to Propionibacterium acnes: an unexpected cause of Prosthetic Valve Dysfunction introduction and objectives. To determine the characteristics of Propionibacterium acnes prosthetic valve endocarditis (PAPVE). Methods. Prospective descriptive study of 16 consecutive cases of PAPVE. results. Seven patients developed PAPVE early and 9 developed it late. In all those who developed PAPVE late, there was a history of mucocutaneous barrier manipulation. The delay in diagnosis was >3 months in 75%. The clinical presentation was asymptomatic prosthetic valve dysfunction in 31%, heart failure in 19%, coronary syndrome in 12.5%, fever in 25%, and neurological deficits in 19%. At diagnosis, 62.5% had heart failure and 44% had fever. The predominant echocardiographic finding was prosthesis dysfunction due to dehiscence of metallic aortic valves (6 out of 7) or stenosis of metallic mitral valves (4 out of 7). In 2 of the 3 biological aortic prostheses, dysfunction was due to leaflet distortion. Blood cultures and surgical specimens tested positive after a mean of 11.6 and 12.2 days, respectively. In 2 cases, the diagnosis was confirmed by PCR. The principle intraoperative finding was the presence of abundant grayish pannus. Histology demonstrated the absence of acute inflammatory features. Twelve patients received antibiotic treatment with valve replacement: 7 were cured, 4 experienced early prosthesis dehiscence and 1 relapsed. All 3 patients who were initially treated with antibiotics alone suffered relapses. conclusions. Generally, PAPVE presents as prosthetic valve dysfunction with few symptoms of infection. Prolonged incubation of cultures is essential for diagnosis. Antibiotic treatment provides clinical control but does not eradicate the infection, and valve replacement is necessary for a cure. The postoperative course can be complicated by prosthesis dehiscence.Rev Esp Cardiol. 01/2009; 62:167-77. -
Article: Insights in the pathogenic potential of Propionibacterium acnes from its complete genome.
[show abstract] [hide abstract]
ABSTRACT: One of the long-lasting open questions in understanding acne is the role of the skin bacterium Propionibacterium acnes. Opinions within the scientific community diverge regarding the importance of this Gram-positive bacterium not only in acne but also in other P. acnes-associated diseases. The recently decoded genome gives us some clues with respect to its pathogenic potential and its strategies to survive in the harsh environment of human skin. This review focuses on the major findings of the genome sequence. Special attention has been drawn to the cell surface composition of P. acnes, its antigenic potential, and to enzymes that are potentially involved in degrading skin-derived substances.Seminars in Cutaneous Medicine and Surgery 07/2005; 24(2):67-72. · 2.50 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed.
The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual
current impact factor.
Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence
agreement may be applicable.
Keywords
multiple mycotic aneurysms
P acnes
Propionibacterium acnes endocarditis
prosthetic valve endocarditis
rare disease
