False-positive and false-negative rates in meconium drug testing.

US Drug Testing Laboratories, Chicago, IL 60612, USA.
Clinical Chemistry (Impact Factor: 7.77). 12/1995; 41(11):1614-6.
Source: PubMed

ABSTRACT To determine the number of false-negative results produced by inefficient extraction of drugs from meconium, three published procedures were compared by using previously confirmed positive and negative meconium specimens. The methods were not equivalent in their ability to extract drugs from the matrix. To determine the number of false positives reported by the use of screen-only (unconfirmed) results, 535 screen-positive meconium specimens were subjects to confirmation by gas chromatography-mass spectrometry. Fifty-seven percent of the samples were confirmed positive for one or more of the drugs under investigation, showing that a false-positive rate as high as 43% may exist when unconfirmed screening results are used.

1 Follower
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Drug testing continues to develop as a necessary strategy to control substance use in the workplace. No one would dispute that alcohol and drug use costs employers billions of dollars in lost productivity, increased liability exposure, and higher workers' compensation insurance premiums. The prevalence of alcohol and drug testing procedures varies across industry groups. Drug testing is often referred to as an intrusive surveillance procedure where "ninety-one percent of the positive results, on confirmation, would be found to be false" (Council on Scientific Affairs, 1987, p. 3110). Particularly with trace detection technology, there is very little empirical evidence to validate this technology as a stand-alone screening system for drug detection and even more limited scientific data on the experiences of those who have had false positive test results generated by this technology. Using a phenomenological and case study theory approach to data collection and analysis, the goals of this qualitative study was to investigate trace detection technology as a standalone method of drug testing by exploring the lived experiences of commercial truck drivers who have experienced false-positive drug test results, and how those positive results have impacted the emotional and physical wellbeing of the individual commercial truck driver. The study findings were based on interviews of commercial truck drivers who have tested positive for drug use. Recommendations on the efficacy of trace detection technology as a reliable drug screening strategy was discussed as well as implications for practice, study limitations, and the future research. Access full doucment at: d=79356&RQT=309&VName=PQD
    1st edited by Capella University Dissertation, 10/2006; ProQuest Information and Learning Company., ISBN: 0542656205
  • Encyclopedia of Analytical Chemistry, 09/2006; , ISBN: 9780470027318
  • Clinical Pharmacokinetics 07/1996; 31(1). DOI:10.2165/00003088-199631010-00007 · 5.49 Impact Factor

Full-text (2 Sources)

Available from
Mar 9, 2015