Parvovirus infection mimicking systemic lupus erythematosus.
ABSTRACT There are striking similarities between human parvovirus B19 (HPV-B19) infection and systemic lupus erythematosus (SLE): both may present with malar rash, fever, arthropathy, myalgia, cytopenia, hypocomplementemia, anti-DNA, and antinuclear antibodies (ANA). Therefore, it is difficult at times to differentiate HPV-B19 infection from SLE presentation or exacerbation. We report 4 cases of HPV-B19 infection mimicking SLE and review 10 other reported cases, all of whom were women. The similarity to a typical SLE presentation was indeed striking: most patients presented with rash, arthropathy, myalgia, fever, and positive ANA. In some cases, HPV-B19 infection seemed to exacerbate SLE rather then resemble it, and differentiation was difficult. Nearly all patients improved within several weeks. However, a few patients had symptoms and laboratory abnormalities lasting more than 6 months. The possibility of HPV-B19 infection should be entertained in patients presenting with SLE-like features.
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ABSTRACT: Abstract The distinctions between infection, chronic arthritis, and autoimmune diseases have steadily blurred over the past decades. The proposed pathomechanisms underlying these interesting associations include putative pathways from infection to innate and adaptive immunity, molecular mimicry, and certain microbial and host factors. This article further reviews the spectrum of microbial agents implicated in some rheumatic diseases and cites the potential clinical application of this expanding field of knowledge in the prevention and treatment of chronic inflammatory and autoimmune diseases.Modern Rheumatology 06/2003; 13(2):97-102. DOI:10.3109/s01007-003-0206-x · 2.21 Impact Factor
Article: Lupus mimickers.[Show abstract] [Hide abstract]
ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multisystem organ involvement, heterogeneity of clinical features, and variety in degree of severity. The differential diagnosis is a crucial aspect in SLE as many other autoimmune diseases portray clinical similarities and autoantibody positivity. Lupus mimickers refer to a group of conditions that exhibit both clinical features and laboratory characteristics, including autoantibody profiles that resemble those present in patients with SLE, and prompt a diagnostic challenge in every-day clinical practice. Thus, lupus mimickers may present as a lupus-like condition (i.e., 2 or 3 criteria) or as one meeting the classification criteria for SLE. Herein we review and classify the current literature on lupus mimickers based on diverse etiologies which include infections, malign and benign neoplasms, medications, and vaccine-related reactions.Autoimmunity reviews 05/2014; DOI:10.1016/j.autrev.2014.05.002 · 7.10 Impact Factor
Medicine - Programa de Formación Médica Continuada Acreditado 08/2013; 8(29):1539–1541. DOI:10.1016/S0304-5412(00)70296-4