[Show abstract][Hide abstract] ABSTRACT: Orientadora : Valéria Sperandio Roxo Dissertaçăo (mestrado) - Universidade Federal do Paraná, Setor de Cięncias Biológicas, Programa de Pós-Graduaçăo em Genética. Defesa: Curitiba, 2008 Inclui bibliografia e anexo
[Show abstract][Hide abstract] ABSTRACT: Schizophrenia is a severe neuropsychiatric disorder with a polygenic mode of inheritance which is also governed by non-genetic
factors. Candidate genes identified on the basis of biochemical and pharmacological evidence are being tested for linkage
and association studies. Neurotransmitters, especially dopamine and serotonin have been widely implicated in its etiology.
Genome scan of all human chromosomes with closely spaced polymorphic markers is being used for linkage studies. The completion
and availability of the first draft of Human Genome Sequence has provided a treasure-trove that can be utilized to gain insight
into the so far inaccessible regions of the human genome. Significant technological advances for identification of single
nucleotide polymorphisms (SNPs) and use of microarrays have further strengthened research methodologies for genetic analysis
of complex traits. In this review, we summarize the evolution of schizophrenia genetics from the past to the present, current
trends and future direction of research.
Journal of Biosciences 02/2002; 27(1):35-52. DOI:10.1007/BF02703682 · 2.06 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.