Article

High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic.

International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 02/1995; 39(1):245-6. DOI: 10.1128/AAC.39.1.245
Source: PubMed

ABSTRACT In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.

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