Autism as a strongly genetic disorder: evidence from a British twin study.
ABSTRACT Two previous epidemiological studies of autistic twins suggested that autism was predominantly genetically determined, although the findings with regard to a broader phenotype of cognitive, and possibly social, abnormalities were contradictory. Obstetric and perinatal hazards were also invoked as environmentally determined aetiological factors. The first British twin sample has been re-examined and a second total population sample of autistic twins recruited. In the combined sample 60% of monozygotic (MZ) pairs were concordant for autism versus no dizygotic (DZ) pairs; 92% of MZ pairs were concordant for a broader spectrum of related cognitive or social abnormalities versus 10% of DZ pairs. The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci. Obstetric hazards usually appear to be consequences of genetically influenced abnormal development, rather than independent aetiological factors. Few new cases had possible medical aetiologies, refuting claims that recognized disorders are common aetiological influences.
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ABSTRACT: In the modern scientific and professional environment psychoanalytic psychotherapy is placed in the background regarding its possibilities in the treatment of autism. This position, expressed by the question of possibilities of its use in the therapy of autism, is identified by the author as a result of the existing dichotomy (‘splitting’) in ‘organic’ and ‘psychic’ concepts of its etiology. To overcome the above constraint the author, on the base of his twenty years of psychotherapeutic experiences with eight autistic children, suggests the possibility of developing such concept of autistic psychogenesis and based on it a therapeutic approach. In support of his therapeutic observations, in this article were used contributions of contemporary researches by intersubjectivists, whose results speak in favour of the thesis.Journal of Psychology and Clinical Psychiatry. 02/2015; 2(2):1-12.
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ABSTRACT: This article is part of a Special 15th Anniversary Issue. Copyright © 2014 Elsevier Inc. All rights reserved.Epilepsy & Behavior 11/2014; 40:37-41. · 2.06 Impact Factor
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ABSTRACT: Autism Spectrum Disorders (ASD) are complex neurodevelopmental disorders characterized by repetitive behavior and impaired social communication and interactions. Apart from these core symptoms, a significant number of ASD individuals display higher levels of anxiety and some ASD individuals exhibit impaired emotional learning. We therefore sought to further examine anxiety and emotional learning in an environmentally induced animal model of ASD that utilizes the administration of the known teratogen, valproic acid (VPA) during gestation. Specifically we exposed dams to one of two different doses of VPA (500 and 600 mg/kg) or vehicle on day 12.5 of gestation and examined the resultant progeny. Our data indicate that animals exposed to VPA in utero exhibit enhanced anxiety in the open field test and normal object recognition memory compared to control animals. Animals exposed to 500 mg/kg of VPA displayed normal acquisition of auditory fear conditioning, and exhibited reduced extinction of fear memory and normal litter survival rates as compared to control animals. We observed that animals exposed to 600 mg/kg of VPA exhibited a significant reduction in the acquisition of fear conditioning, a significant reduction in social interaction and a significant reduction in litter survival rates as compared to control animals. VPA (600 mg/kg) exposed animals exhibited similar shock sensitivity and hearing as compared to control animals indicating the fear conditioning deficit observed in these animals was not likely due to sensory deficits, but rather due to deficits in learning or memory retrieval. In conclusion, considering that progeny from dams exposed to rather similar doses of VPA exhibit striking differences in emotional learning, the VPA model may serve as a useful tool to explore the molecular and cellular mechanisms that contribute to not only ASD, but also emotional learning.Frontiers in Behavioral Neuroscience 11/2014; 8:387. · 4.16 Impact Factor
Bailey A, Le Couteur A, Gottesman I,
Bolton P, Simonoff E, Yuzda E, Rutter M.
1995. Autism as a strongly genetic
disorder: evidence from a British twin
study. Psychol Med 25(1):63-77.
23/25 Identical Twin Pairs = 92%
2/20 Fraternal Twin Pairs =10%
Concordant for ASD =~.91H