Relapse criteria in schizophrenic disorders: Different perspectives
Leiden University, Leyden, South Holland, Netherlands Psychiatry Research
(Impact Factor: 2.47).
01/1995; 54(3):273-81. DOI: 10.1016/0165-1781(94)90021-3
Relapse and exacerbation of psychotic symptoms were investigated in a prospective study of 88 patients with recent-onset schizophrenia and related disorders. Relapse definitions were derived from expressed emotion and family intervention studies and based on the Brief Psychiatric Rating Scale (BPRS), the Present State Examination, and clinical judgment. Results indicate that research and clinical criteria represent different perspectives on relapse. Clinical criteria provide a validity check that can verify BPRS-rated changes in partially remitted patients.
Available from: Derek Mclaughlin
- "Parker (2005) argued that the rates of illicit drug use in NI are similar, but slightly lower than that elsewhere in the UK. Kamali et al. (2000) found that those using substances reported more suicidal thoughts compared with past or non-substance users, a factor supported by the NI government's mental health strategy (Department of Health Social Services and Public Safety 2003a). 1 Linszen et al. (1994) concluded that significantly more psychotic relapses occurred with people who used cannabis, noting that use causes relapse in patients with schizophrenia. Moreover, McCrone et al. (2000) reported that a greater proportion of patients with dual diagnosis used inpatient care and emergency clinic services. "
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ABSTRACT: This qualitative, exploratory study was designed to explore a sample of eight recently appointed dual diagnosis workers' (DDWs) perceptions of their new role and function in Northern Ireland (NI). A semi-structured interview was used and respondents were assured that their anonymity/rights would be protected. All of the narratives were shown to the respondents for their approval prior to going to press. The transcripts were analysed by using a tried and tested analytical framework. Seven key categories emerged from the findings relating to the DDWs perceptions of their: (1)understanding of the term dual diagnosis; (2) hopes; (3) fears; (4) support in their new role; (5) key clinical issues; (6) the positioning of the service; and (7) their overall role and function. This is a new and important area of work in NI. However, to date, no research has been carried out on the topic in the province. Consequently, the findings from this small study could go some way towards helping to shape the future direction of, and bring about some universality to the provision of the dual diagnosis service within different National Health Service Trusts in NI. Further research is required on this new and growing service as well as on the service users' perceptions of the care provided by DDWs. The study will be followed up on an annual basis for 3 years to provide longitudinal data. Generalization of findings requires caution because of the small sample size.
Journal of Psychiatric and Mental Health Nursing 04/2008; 15(4):296 - 305. DOI:10.1111/j.1365-2850.2007.01225.x · 0.84 Impact Factor
Available from: Philip Cola
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ABSTRACT: The objective of this study was to report the effect of the slow withdrawal of clozapine from 19 patients with neuroleptic-responsive schizophrenia at the end of a 2-year clinical trial of clozapine and to compare this with the results of naturalistic discontinuation of clozapine treatment in 64 neuroleptic-resistant schizophrenic patients. Nineteen neuroleptic-responsive schizophrenic patients who received clozapine were withdrawn from clozapine by tapering it over 3-week period with and without the addition of a typical neuroleptic. Fifteen of the 19 neuroleptic-responsive patients experienced the return of psychotic symptoms during or after the clozapine taper, which were most severe in the ten patients in whom the withdrawal of clozapine was carried out without prior addition of neuroleptic treatment. Addition of a neuroleptic prior to clozapine withdrawal prevented the emergence of positive symptoms during clozapine withdrawal in each of eight patients. Nevertheless, psychotic symptoms emerged, usually within a week after discontinuing clozapine, in six of the eight patients. Neuroleptic treatment, with or without an anticholingergic drug, was much less effective in treating positive symptoms in these patients immediately after the clozapine withdrawal than it had been 2 years previously. Cyproheptadine, a non-selective serotonin receptor antagonist, augmented the antipsychotic effect of neuroleptics in each of four patients who relapsed following withdrawal from clozapine and relieved extrapyramidal symptoms in a fifth patient. The frequency of relapse following withdrawal of clozapine in 64 neuroleptic-resistant patients was significantly lower (25/64, 39.1%) than in the neuroleptic-responsive patients.
Psychopharmacology 04/1996; 124(1-2):176-87. DOI:10.1007/BF02245619 · 3.88 Impact Factor
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