Article

Inhalation sedation with sevoflurane: a comparative study with nitrous oxide.

1st Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
Journal of Oral and Maxillofacial Surgery (impact factor: 1.64). 02/1995; 53(1):24-6; discussion 26-7. pp.24-6; discussion 26-7
Source: PubMed

ABSTRACT To evaluate the possibility of using sevoflurane for inhalation sedation.
Thirty-five volunteers were divided randomly into two groups: sevoflurane group (n = 20) and nitrous oxide (N2O) group (n = 15). At the beginning of the sedation they all inhaled 100% O2, then a 0.1 minimum alveolar concentration (MAC) of sevoflurane or 10% N2O with oxygen, a 0.2 MAC of sevoflurane or 20% N2O with oxygen, and 0.3 MAC of sevoflurane or 30% N2O with oxygen for 10 minutes each.
The respiratory and cardiovascular functions were stable during inhalation of the gas mixtures. There were five negative comments about breathing N2O, but none about breathing sevoflurane.
All subjects in the sevoflurane group stated they would be willing to submit to the same inhalation procedure again.

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    S Ganzberg, J Weaver, F M Beck, G McCaffrey
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    ABSTRACT: This study attempted to determine if sevoflurane in oxygen inhaled via a nasal hood as a sole sedative agent would provide an appropriate level of deep sedation for outpatient third molar surgery. Twenty-four patients scheduled for third molar removal were randomly assigned to receive either nasal hood inhalation sevoflurane or an intravenous deep sedation using midazolam and fentanyl followed by a propofol infusion. In addition to measuring patient, surgeon, and dentist anesthesiologist subjective satisfaction with the technique, physiological parameters, amnesia, and psychomotor recovery were also assessed. No statistically significant difference was found between the sevoflurane and midazolam-fentanyl-propofol sedative groups in physiological parameters, degree of amnesia, reported quality of sedation, or patient willingness to again undergo a similar deep sedation. A trend toward earlier recovery in the sevoflurane group was identified. Sevoflurane can be successfully employed as a deep sedative rather than a general anesthetic for extraction of third molars in healthy subjects.
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Keywords

0.1 minimum alveolar concentration
 
10 minutes
 
breathing N2O
 
breathing sevoflurane
 
cardiovascular functions
 
gas mixtures
 
inhalation sedation
 
MAC
 
nitrous oxide
 
respiratory
 
sedation
 
sevoflurane
 
sevoflurane group
 
sevoflurane group stated
 
volunteers
 

N Haraguchi