Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn.)

Department of Biochemistry, University of Kerala, Trivandrum.
Indian journal of physiology and pharmacology 08/1994; 38(3):220-2.
Source: PubMed


A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats. It's action is closely similar to that of an effective dose of glibenclamide (2 mg/kg) tested under the same conditions. However, after a glucose load the plant product is only just significantly active but not as effective as the sulphonylurea. The efficacy of the plant product as a hydroglycemic agent adds to its other therapeutic effects, as it belongs to the class of flavonoids.

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    • "Oral administration of bark extract showed significant antihyperglycemic effect in STZ diabetic rats by raising serum insulin levels. Leucocyanidin and pelargonidin compounds (Scheme 1) isolated from the bark have also shown hypoglycemic activity [63–65]. Most recently, the hypoglycemic as well as antidiabetic properties have been reported in aerial roots of this tree [66]. "
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    ABSTRACT: The demand for interdisciplinary research is increasing in the new millennium to help us understand complex problems and find solutions by integrating the knowledge from different disciplines. The present review is an excellent example of this and shows how unique combination of physics, chemistry, and biological techniques can be used for the evaluation of Indian medicinal herbs used for treating diabetes mellitus. Laser-induced breakdown spectroscopy (LIBS) is a sensitive optical technique that is widely used for its simplicity and versatility. This review presents the most recent application of LIBS for detection of glycemic elements in medicinal plants. The characteristics of matrices, object analysis, use of laser system, and analytical performances with respect to Indian herbs are discussed.
    Evidence-based Complementary and Alternative Medicine 10/2013; 2013(1):406365. DOI:10.1155/2013/406365 · 1.88 Impact Factor
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    • "Pickle and processed candies of C. axillaris are popular among the natives in Far Western Nepal; however, its potential as timber and medicine source was under-recognized. The hypoglycemic effects of different compounds obtained from F. benghalensis have been reported (Geetha et al. 1994). The plant produces taxifolin, which exhibits anti-inflammatory property (Darwish 2002), and its latex is considered as a hair-growth promoter (Kala et al. 2004). "
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    ABSTRACT: Underutilized plant species help to alleviate common food insufficiencies by providing alternative food supply. They also complement primary health care, furnishing raw materials where the cultivation of staple cereal crops is least feasible and health care is pursued indigenously. Research and promotion of extraction, utilization, and conservation of underutilized species lead to exploration of new staple crops and motivate people to consume in a sustainable manner. The present study describes the current status, uses, and management of underutilized plant species in Far West Nepal. The relative importance of 49 underutilized plant species was computed employing a Relative Importance (RI) technique. The use-values assigned to the species fall into six use-categories: beverage, fodder, food & edible, medicinal, vegetable and veterinary. A total of 22 species appeared in multiple use-categories, while the rest were characterized by a single use-category. Based on relative importance and frequency, Ficus semicordata, Debregesia longifolia, Girardinea diversifolia, Hydrocotyle nepalensis, Garuga pinnata, Aloe vera and Pyrus pashia offer the most potential for future. Underutilized plants proved important to folk medicine and food. These species persist because they remain useful to local people as means of subsistence, production, and primary health care. The findings are important so far as they point up the role of underutilized plants in national food security policy and health care, spelling out their potentialities and cross cutting relationships.
    Journal of Mountain Science 08/2013; 9(5). DOI:10.1007/s11629-012-2315-8 · 0.96 Impact Factor
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    • "The fruit extract of F. benghalensis exhibited antitumor activity (Mousa et al., 1994). This plant has also been used for the treatment of diarrhea and dysentery piles (Uma et al., 2009) and as a hypoglycemic agent (Augusti, 1975; Geetha et al., 1994). The extracts of F. benghalensis inhibited insulin's action (Chrekar et al., 1991). "
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    ABSTRACT: Aim: Present study was conducted to evaluate the dermatoprotective effects of plant extracts (Ficus religiosa, Ficus benghalensis, and Ficus racemosa) against known irritants such as sodium dodecyl sulfate (SDS), atrazine, and petrol. METHODS: The study was conducted in adult male rabbits. Ethanol extracts of plants were obtained through Soxhlet. All irritants and Ficus extracts were topically applied to the backs of rabbits daily for 4 days, while pure ethanol served as control. Skin was examined after 24, 48, and 96 h for erythema. Skin biopsies were taken on 5th day for microscopic examination. RESULTS: Erythema produced by irritants reduced significantly with the simultaneous application of Ficus extracts. The mean ± SEM epidermal thickness (micrometer) with SDS was 45.40 ± 1.89, F. religiosa + SDS was 18.60 ± 0.51, F. benghalensis + SDS was 18.40 ± 0.25, F. racemosa + SDS was 18.80 ± 0.37, and mixture of three Ficus species + SDS was 16.80 ± 0.37. Similar findings were revealed after using plant extracts with atrazine and petrol. The mean ± SEM epidermal layer count for SDS was 3.60 ± 0.25, atrazine was 3.40 ± 0.25, petrol was 3.40 ± 0.25, and ethanol (control) was 1.00 ± 0.20. This count reduced to 1.20 ± 0.20 for three Ficus species + SDS, 1.40 ± 0.25 for Ficus species + atrazine, and 1.40 ± 0.25 for Ficus species + petrol. CONCLUSION: Ficus species demonstrated the potential to block the dermatotoxic effects of topical irritants and could be used successfully to prevent skin toxicity.
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