Hypoglycemic effects of leucodelphinidin derivative isolated from Ficus bengalensis (Linn.)
ABSTRACT A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats. It's action is closely similar to that of an effective dose of glibenclamide (2 mg/kg) tested under the same conditions. However, after a glucose load the plant product is only just significantly active but not as effective as the sulphonylurea. The efficacy of the plant product as a hydroglycemic agent adds to its other therapeutic effects, as it belongs to the class of flavonoids.
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ABSTRACT: Underutilized plant species help to alleviate common food insufficiencies by providing alternative food supply. They also complement primary health care, furnishing raw materials where the cultivation of staple cereal crops is least feasible and health care is pursued indigenously. Research and promotion of extraction, utilization, and conservation of underutilized species lead to exploration of new staple crops and motivate people to consume in a sustainable manner. The present study describes the current status, uses, and management of underutilized plant species in Far West Nepal. The relative importance of 49 underutilized plant species was computed employing a Relative Importance (RI) technique. The use-values assigned to the species fall into six use-categories: beverage, fodder, food & edible, medicinal, vegetable and veterinary. A total of 22 species appeared in multiple use-categories, while the rest were characterized by a single use-category. Based on relative importance and frequency, Ficus semicordata, Debregesia longifolia, Girardinea diversifolia, Hydrocotyle nepalensis, Garuga pinnata, Aloe vera and Pyrus pashia offer the most potential for future. Underutilized plants proved important to folk medicine and food. These species persist because they remain useful to local people as means of subsistence, production, and primary health care. The findings are important so far as they point up the role of underutilized plants in national food security policy and health care, spelling out their potentialities and cross cutting relationships.Journal of Mountain Science 08/2013; 9(5). DOI:10.1007/s11629-012-2315-8 · 0.76 Impact Factor
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ABSTRACT: Zanthoxylum rhetsa (Roxb.) DC. known to the Kanikkars as "Malvapoou" is an important medicinal plant. The Kanikkar tribe, inhabitants of the Agasthiarmalai Biosphere Reserve, Western Ghats, Tamil Nadu, applied the paste prepared by rubbing the hard spines on the rock along with water on the breast to give relief from pain and increase lactation in nursing mothers. From the exhaustive literature survey, it is found that so far no proper pharmacognostical and phytochemical studies of spine of Zanthoxylum rhetsa have been reported. The present investigation deals with the pharmacognostic studies of the spine of the said plant. Pharmacognostic studies include microscopic, physicochemical constants (ash & extractive values), fluorescence analysis and preliminary phytochemical evaluations. INTRODUCTION Plant materials are used throughout developed and developing countries as home remedies, over the counter drug products and raw materials for the pharmaceutical industry and represent a substantial proportion of the global drug market. It is therefore essential to establish internationally recognized guidelines for assessor their quality (Rajesh et al., 2010).There is a need for documentation of research work carried out on traditional medicines. With this back drop, it becomes extremely important to make an effort towards standardization of the plant material to be used as medicine. The process of standardization can be achieved by stepwise pharmacognostic studies (Ozarkar, 2005). These studies help in identification and authentication of the plant material. Correct identification and quality assurance of the starting materials is an essential prerequisite to ensure reproducible quality of herbal medicine which will contribute to its safety and efficacy, simple pharmacognostic techniques used in standardization of plant material include its morphological, anatomical and biochemical characteristics (Anonymous, 1998). The Zanthoxylum rhetsa (Roxb.) DC. belongs to the family Rutaceae. It is commonly known as "Malvapoou" in Kanikkar tribals of Agasthiarmalai Biosphere Reserve, Western Ghats, Tamil Nadu. Kanikkar tribes applied the paste prepared by rubbing the hard spines on a rock along with water on the breast to give relief from pain and increase lactation in nursing mothers (Lalitharani and Mohan, 2010). However, perusal of literature reveals that, pharmacognostic information on Zanthoxylum rhetsa spine totally lacking, hence in the present investigation was undertaken. The objective of the present study is to evaluate various pharmacognostic standards like microscopy, physico-chemical constant, fluorescence analysis and preliminary phytochemical analysis of Zanthoxylum rhetsa (Roxb.)DC spines.Bioscience Discovery 01/2013; 4(1):5-11. · 0.39 Impact Factor
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ABSTRACT: Diabetes mellitus is a metabolic disorder prevailing throughout the world irrespective of age, sex and race. The present study deals with phytochemical, antioxidant, antihyperglycaemic and antihyperlipidemic potential of Origanum majorana (OM) leaves. Various extracts of OM were used for the study such as, hydrodistilled volatile oil (OMO), petroleum ether extract (OMPE), methanolic extract (OMM) and aqueous extract (OMW). Three doses of each extract viz. 100, 200 and 400 mg/kg p.o. were used for the study. Streptozotocin, STZ (65 mg/Kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non insulin dependent diabetes mellitus (NIDDM) in rats. Various biochemical markers of blood and tissue origin were estimated. The results were statistically analyzed by ANOVA followed by Dunnett’s test. Glibenclamide, a well known antidiabetic drug, was used as a standard. Volatile oil (OMO, 200 and 400 mg/kg p.o.) and methanolic extract (OMM, 200 and 400 mg/kg p.o.) exhibited dose dependent significant (p < 0.01) antihyperglycaemic activity. The aqueous (OMW, 200 and 400 mg/kg p.o.) had moderate (p < 0.05) effect on blood sugar level. The volatile oil (OMO, 100 mg/kg p.o.) was less significant (p < 0.05) in lowering the elevated triglyceride and cholesterol levels. Whereas; methanolic (OMM, 200 and 400 mg/kg p.o.) and aqueous (OMW, 200 and 400 mg/kg p.o.) extracts substantially (p < 0.01) showed antihyperlipidemic effect. From this study, it was concluded that the volatile oil and methanolic extract of Origanum majorana leaves could prove to be beneficial in management of NIDDM and its associated lipid imbalance.Oriental Pharmacy and Experimental Medicine 03/2011; 12(1). DOI:10.1007/s13596-011-0047-x