Article

Down-regulation of imidazoline sites in rabbit kidney.

Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
European Journal of Pharmacology (impact factor: 2.52). 11/1993; 243(1):95-7. DOI:10.1016/0014-2999(93)90174-G pp.95-7
Source: PubMed

ABSTRACT The effects of 6 days treatment with guanabenz, clonidine, rilmenidine and idazoxan on [3H]idazoxan and [3H]clonidine binding to imidazoline sites on rabbit kidney membranes were compared. Guanabenz and rilmenidine treatment resulted in a decrease in Bmax for [3H]clonidine binding and guanabenz treatment for [3H]idazoxan binding consistent with the compounds in vitro affinities for the imidazoline binding sites. [3H]Idazoxan binding was also decreased by idazoxan treatment suggesting that idazoxan may act as an agonist at this site. These results show that imidazoline sites in kidney may be modified during chronic drug treatment and provide further evidence for differences between the sites labelled by the two ligands.

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Keywords

6 days treatment
 
[3H]idazoxan
 
[3H]Idazoxan binding
 
[3H]idazoxan binding consistent
 
chronic drug treatment
 
compounds
 
Guanabenz
 
guanabenz treatment
 
idazoxan treatment
 
imidazoline binding sites
 
imidazoline sites
 
kidney
 
rabbit kidney membranes
 
rilmenidine
 
rilmenidine treatment
 
sites labelled
 
two ligands
 
vitro affinities
 

C A Hamilton