A comparison between digitally-guided fine needle aspiration and ultrasound-guided transperineal core needle biopsy of the prostate for the detection of prostate cancer.
ABSTRACT To prospectively examine the accuracy of fine needle aspiration (FNA) for the detection of prostate cancer. Ultrasound-guided core needle biopsy of the prostate was used as the standard to which the FNA results were compared.
One-hundred patients who had been referred for urological evaluation were suspected of having prostate cancer on the basis of digital rectal examination (DRE) and/or transrectal ultrasound (TRUS). All were further evaluated by digitally guided transrectal FNA and by TRUS-guided transperineal core needle biopsy.
Prostate cancer was identified in 54 patients by core needle biopsy and in 45 by FNA. The sensitivity of FNA was 81% and both specificity and positive predictive value were 98%.
FNA is easily performed, has negligible morbidity and offers prompt results. These data suggest that FNA is a reasonable initial diagnostic procedure for the detection of prostate cancer. Core needle biopsy may be reserved for patients with negative cytology who are clinically suspected of having prostate cancer. In selected patients, FNA may be used as an alternative to core needle biopsy for diagnosis, treatment planning and follow-up.
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ABSTRACT: In this study we analysed 1355 patients, who had undergone a radical prostatectomy because of prostate cancer at the Klinikum Rechts der Isar between 1984 and 2001, to work out at-risk groups for a PSA-failure after radical prostatectomy because of a clinical localiced prostate cancer. Employing uni- and multivariate analysis we detected ultimately the following 5 significant factors, which allow to forecast the propability of PSA-failure: "year of the surgery", "pre-operative PSA", "grade", "clinical stage (pT-category)" and "PSA-density". Depending on many factors, such as the surgeon, the method of surgery etc., the variable "year of the surgery" seems to be unqualified. The prognostic benefit of the factors "pre-operative PSA", "grade" and "clinical stage" has been confirmed in the literature. The importance of the variable "PSA-density" hasn´t been secured adequately yet.01/2006;
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ABSTRACT: A brief review of the history of transrectal fine-needle aspiration (FNA) of the prostate gland is reported in this article; the authors'experience of FNA during the last 20 yr is described also. Despite the worldwide acceptance of the thin-needle core approach, the use of transrectal FNA of palpable abnormalities of the prostate still is advocated because it is cheaper, faster, easier to perform, and results in lower morbidity than any other technique so far developed. High sensitivity, specificity, and efficacy account for its reliability. Appropriate training in performing transrectal FNA of the prostate and in interpreting the smears is, of course, essential. Transrectal FNA should be the initial diagnostic procedure for suspected prostatic cancer and will continue to be a useful diagnostic tool in the 21st century.Diagnostic Cytopathology 06/2005; 32(5):315-20. · 1.49 Impact Factor
- BJU International 08/2008; 85(1):87 - 94. · 3.05 Impact Factor