A Multicenter Double-Blind Trial of Paroxetine Versus Amitriptyline in Depressed Inpatients

Department of Psychiatry, Innsbruck University Hospital, Austria.
Journal of Clinical Psychopharmacology (Impact Factor: 3.24). 08/1994; 14(4):241-6. DOI: 10.1097/00004714-199408000-00003
Source: PubMed


The phenylpiperidine derivative paroxetine is a selective serotonin reuptake inhibitor. In a double-blind 6-week trial, paroxetine was compared with amitriptyline in hospitalized patients suffering from major depression (DSM-III). One hundred fifty-three patients were enrolled in the study in seven centers in Austria and Germany. Results showed similar efficacy of both drugs after 6 weeks. The differences between groups in Montgomery-Asberg Depression Rating Scale and Clinical Global Impression ratings did not reach statistical significance at any time. Side effects were distributed similarly but with a significantly higher incidence of anticholinergic effects in patients treated with amitriptyline (p < or = 0.001), whereas agitation and insomnia were registered more often in the paroxetine group. This study supports the antidepressive efficacy of paroxetine in a sample of severely depressed inpatients.

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