Damage to murine kidney and intestine from exposure to the fields of a piezoelectric lithotripter.

Abstract

Earlier studies, in which murine kidneys were exposed to spherically diverging, spark-generated shock waves, demonstrated extensive hemorrhage in the interior of the organ at peak positive pressures somewhat less than 10 MPa. With comparable pulse numbers, this investigation, using the focal fields of a piezoelectric lithotripter, found no damage to murine kidneys at peak positive pressures as high as 40 MPa. Comparison of these cases and earlier bioeffects studies using pulsed, focused ultrasound leads to the conclusion that damage to murine kidneys is not simply correlated with peak positive pressure or peak negative pressure, nor is spectral content of the wave able to explain the striking differences in damage from these sources. With 200 individual shock waves from the piezoelectric lithotripter applied ventrally, 20-30% of the animals suffered superficial kidney damage (bleeding into the capsule), but the same exposure conditions produced severe intestinal hemorrhage in more than 80% of the animals.