Article

An unusual distribution of glucose-6-phosphate dehydrogenase deficiency of south Indian newborn population.

Department of Biochemistry, Indian Institute of Science, Bangalore.
Indian journal of biochemistry & biophysics (impact factor: 1.14). 09/1994; 31(4):358-60. pp.358-60
Source: PubMed

ABSTRACT Glucose-6-phosphate dehydrogenase (G6PD) deficiency is seen at a higher frequency in many national and ethnic groups in areas of current or former malaria endemicity. A screening programme undertaken to evaluate the gene frequencies for this deficiency in the highly inbred South Indian population of Karnataka revealed that of the 5140 neonates screened, 7.8% were G6PD deficient with no correlation between the reported level of inbreeding and enzyme deficiency. An interesting finding was the equal number of male (198) and female (207) individuals, with G6PD activity of less than 3 IU. The possible implications of this finding with regard to the expression of G6PD gene is discussed.

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Keywords

equal number
 
ethnic groups
 
former malaria endemicity
 
G6PD gene
 
gene frequencies
 
Glucose-6-phosphate dehydrogenase
 
inbred South Indian population
 
inbreeding
 
interesting
 
Karnataka
 
reported level