Schizophrenia and prenatal exposure to the 1957 A2 influenza epidemic in Croatia

Department of Psychiatry, Columbia University, New York, NY 10032.
American Journal of Psychiatry (Impact Factor: 12.3). 11/1994; 151(10):1496-8.
Source: PubMed


The authors present data from the Republic of Croatia on schizophrenia rates in a birth cohort prenatally exposed to the 1957 A2 influenza epidemic and in comparison (unexposed) birth cohorts. The rate of schizophrenia did not differ significantly between the exposed and unexposed cohorts.

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    • "Since then, a host of ecologic studies attempting to replicate this initial finding have been conducted throughout Europe and in the United States, Japan, and Australia. Positive associations between exposure to the 1957 epidemic and births of preschizophrenia subjects were reported in Great Britain (O'Callaghan et al. 1991; Adams et al. 1993; Fahy et al. 1993; Takei et al. 1993), Ireland (Cannon et al. 1996), Japan (Kunugi et al. 1995), and Australia (McGrath et al. 1994). All but one of those studies showed second trimester specificity for the association. "
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