Vitamin E in a mitochondrial myopathy with proliferating mitochondria.
- SourceAvailable from: sciencedirect.comJournal of Cardiology Cases 08/2012; 6(2):e64–e65. DOI:10.1016/j.jccase.2012.05.004
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ABSTRACT: The computational model for skeletal muscle energetics and oxidative phosphorylation is derived from a previously published model applied to cardiac tissue (5). For the current application the cardiac model has been modified in two ways to adapt the model to analyze data from human skeletal muscle. First, the oxygen transport component of the previous model has been removed. It is assumed that the skeletal muscle remains normoxic during the experiments and the cellular oxygen concentration, (O2), which is a variable in the model of Beard (5), appears as a fixed parameter in the current model. Second, the mitochondrial volume of the muscle cell, which is approximately 30% of cell volume in cardiomyocytes (27), is set to Vmito = 0.056 (l mito) (l cell) -1 , a value measured