Vitamin E in a mitochondrial myopathy with proliferating mitochondria

Department of Biochemistry , Erasmus Universiteit Rotterdam, Rotterdam, South Holland, Netherlands
The Lancet (Impact Factor: 45.22). 08/1993; 342(8864):175-6. DOI: 10.1016/0140-6736(93)91379-Z
Source: PubMed
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    • "Although the diagnosis itself of the patient was controversial, the effect of this therapeutic approach was dramatic and cardiac condition almost fully recovered at least in this case. Although it will be difficult to clarify the role of each material in this unique cocktail in mitochondrial diseases, this kind of " broad approach " might be effective in various types of mitochondrial diseases [12] [13] [14] and may show a novel pharmacological approach to mitochondrial diseases . However, strong attention should be paid to the dosage and method of administration of these materials because they can cause various types of side effects, including hypotension, peripheral vascular injury, cardiogenic shock, or life-threatening arrhythmias. "
    Journal of Cardiology Cases 08/2012; 6(2):e64–e65. DOI:10.1016/j.jccase.2012.05.004
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    ABSTRACT: The computational model for skeletal muscle energetics and oxidative phosphorylation is derived from a previously published model applied to cardiac tissue (5). For the current application the cardiac model has been modified in two ways to adapt the model to analyze data from human skeletal muscle. First, the oxygen transport component of the previous model has been removed. It is assumed that the skeletal muscle remains normoxic during the experiments and the cellular oxygen concentration, (O2), which is a variable in the model of Beard (5), appears as a fixed parameter in the current model. Second, the mitochondrial volume of the muscle cell, which is approximately 30% of cell volume in cardiomyocytes (27), is set to Vmito = 0.056 (l mito) (l cell) -1 , a value measured
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