Evidence for autosomal dominant transmission in Tourette's syndrome. United Kingdom cohort study.
ABSTRACT Complex segregation analyses were performed on families ascertained through 40 unselected consecutive patients with Tourette's syndrome to examine the hypothesis that its transmission is consistent with genetic inheritance. Analyses were done using several diagnostic classifications. All results were consistent with an autosomal dominant gene with high penetrance. The penetrances ranged from 0.882 to 1.000 for males and 0.452 to 0.980 for females, depending upon the specific classification scheme incorporated into the analyses.
Article: Tourette syndrome and tics[Show abstract] [Hide abstract]
ABSTRACT: Tic disorders are not uncommon in children. The classification of the disorders includes transient tic disorders, chronic motor or vocal tic disorders and Tourette syndrome. Tourette syndrome consists of the presence of motor and vocal tics and occurs in 0.5–1.85% of school children. The tics range from blinking and shoulder shrugging to more complex tics such as jumping and the use of inappropriate words. The condition may be associated with other disorders, such as attention deficit hyperactivity disorder and obsessive compulsive disorder. A detailed history is essential in making the diagnosis, and an assessment of the child's functioning and self-esteem is also important in relation to management. A full explanation of the condition to the child and family may be all that is required in mild forms of the disorder. Various forms of management include psychological techniques and medication as well as liaison with the school.Current Paediatrics 02/2003; 13(1):42-46. DOI:10.1054/cupe.2003.0405
Neurology 09/1999; 53(4):825-825. DOI:10.1212/WNL.53.4.825 · 8.30 Impact Factor
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ABSTRACT: Gilles de la Tourette syndrome and conduct disorder (CD) are both heterogeneous childhood onset conditions, and although patients with CD have been described in Gilles de la Tourette syndrome cohorts, little is known about the etiology of CD in Gilles de la Tourette syndrome or of the interrelationships. A cohort of 578 consecutive patients with Gilles de la Tourette syndrome was assessed using standard assessment protocols. A total of 13.5% of participants had only Gilles de la Tourette syndrome, whereas the rest had associated comorbidities and psychopathology. CD occurred in 14.5% of Gilles de la Tourette syndrome probands. These findings suggest that CD is not an integral part of Gilles de la Tourette syndrome but rather that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.The Journal of neuropsychiatry and clinical neurosciences 08/2014; 27(1). DOI:10.1176/appi.neuropsych.13050112 · 2.77 Impact Factor