Sperm morphology and recurrent abortion

Recurrent Miscarriage Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Fertility and Sterility (Impact Factor: 4.59). 05/1994; 61(4):776-8.
Source: PubMed


In 98 men whose partners experienced three or more spontaneous abortions, there were no significant differences in ejaculate volume, concentration of sperm, the percentage of total abnormal sperm, or the percentage of individual sperm defects as compared with normal WHO standards and 17 men fathering successful pregnancies. These data indicate that neither abnormal sperm concentration nor abnormal sperm morphology are significantly associated with recurrent spontaneous abortion.

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    • "In this context, the results of our study were consistent with those of another investigation (Mohamed et al., 2007). According to the study carried out by Hill et al., 1994, irregularities in sperm morphology are implicated in the incidence of RSA. Our study of the RSA group showed a negative correlation between sperm DNA fragmentation, sperm progressive motility and normal sperm morphology. "
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    ABSTRACT: The aim of the present study was to evaluate the degree of sperm DNA fragmentation in couples with idiopathic recurrent spontaneous abortion (RSA) and in those with no history of infertility or abortion. In this cohort study, 30 couples with RSA and 30 fertile couples as control group completed the demographic data questionnaires, and their semen samples were analysed according to World Health Organization (WHO) standards (September 2009-March 2010) for evaluation of sperm DNA fragmentation, using sperm chromatin dispersion (SCD) technique. The percentage of morphologically normal sperm was significantly lower in RSA patients compared with control group (51.50 ± 11.60 versus 58.00 ± 9.05, P = 0.019), but not in other parameters. Additionally, the level of abnormal DNA fragmentation in the RSA group was significantly higher than the control group (43.3% versus 16.7%, P = 0.024). Our results indicated a negative correlation between the number of sperm with progressive motility and DNA fragmentation (r = -0.613; P < 0.001). The sperm from men with a history of RSA had a higher incidence of DNA fragmentation and poor motility than those of the control group, indicating a possible relationship between idiopathic RSA and DNA fragmentation.
    Andrologia 12/2012; 46(2). DOI:10.1111/and.12056 · 1.63 Impact Factor
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    • "At the present time, the following conclusions can be drawn. A similar distribution among RPL men of normal and abnormal TNMC was observed, supporting the concept that conventional method of semen sample analysis (sperm concentration, motility and morphology) does not help to recognize or help to predict male candidates with RPL (Hill et al., 1994; Sbracia et al., 1996; Buckett et al., 1997; Gopalkrishnan et al., 2000). "
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    ABSTRACT: Experiments of double target in-situ hybridization were performed separately for chromosomes 1-17, 8-18 and sex chromosomes on sperm samples from 20 couples suffering from three or more recurrent first trimester abortions. For a subset of this study population, additional experiments of multicolour fluorescence in-situ hybridization for chromosomes 4, 7, 12, 13, 15, 18, 21, and 22, were performed on the bases of the available data from abortive tissue karyotyping. A markedly high rate of sperm disomy (14.5-15.5%) was scored in only two cases. For three other patients, the cumulative disomy rates for chromosomes 1, 17, 8, 18, X and Y also increased but at a lower level (7.8-9.5%). For the remaining 15 patients, the frequency of sperm aneuploidy was moderately increased or normal. Men with recurrent pregnancy loss (RPL) and poor semen quality had baseline sperm aneuploidy and diploidy rates higher than men with normal semen parameters (with or without RPL). Using probes for chromosomes 1, 17, 8, 18, X and Y, significantly elevated frequencies of sperm aneuploidy (not diploidy) were found in 10% of men with a history of RPL. Their rate of sperm aneuploidy was 30-34%. For the other men, changes in sperm aneuploidy were not thought to affect RPL. Poor semen quality per se impacted negatively on sperm aneuploidy and diploidy, thus making the interpretation of clinical data more difficult.
    Reproductive biomedicine online 10/2004; 9(3):312-20. DOI:10.1016/S1472-6483(10)62147-5 · 3.02 Impact Factor
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