Article

Sodium selenite as modulator of red cell shape.

Department of Biochemistry, University of Umeå, Sweden.
Biochimica et Biophysica Acta (impact factor: 4.66). 05/1994; 1191(1):141-6. pp.141-6
Source: PubMed

ABSTRACT Addition of sodium selenite to human red cells, under ATP deplete conditions, induces a rapid oxidation of both glutathione and protein sulphydryl groups. Selenite also inhibits the discocyte-echinocyte shape transformation and stops the process before completion. Parallel to the effect on shape, selenite reduces the dephosphorylation of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-monophosphate. Therefore our results support a shape change mechanism based on the metabolism of phosphoinositides and compatible with the bilayer-couple hypothesis.

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Keywords

ATP deplete conditions
 
bilayer-couple hypothesis
 
discocyte-echinocyte shape transformation
 
metabolism
 
phosphatidylinositol 4,5-bisphosphate
 
phosphatidylinositol 4-monophosphate
 
protein sulphydryl groups
 
rapid oxidation
 
shape change mechanism
 
sodium selenite