Article

Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring

Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
Journal of Ethnopharmacology (Impact Factor: 3). 02/1994; 41(1-2):39-44. DOI: 10.1016/0378-8741(94)90055-8
Source: PubMed

ABSTRACT Valeriana officinalis L. (Valerianaceae) is widely known to be associated with sedative properties. The effects of a valepotriates mixtures on mothers and progeny were evaluated in rats. A 30-day administration of valepotriates did not change the average length of estral cycle, nor the number of estrous phases during this period. Also, there were no changes on the fertility index. Fetotoxicity and external examination studies did not show differences, although internal examination revealed an increase in number of retarded ossification after the highest doses employed--12 and 24 mg/kg. No changes were detected in the development of the offspring after treatment during pregnancy. As for temperature, valepotriates caused a hypothermizant effect after administration by the intraperitoneal route but not after oral administration. Generally, the valepotriates employed induced some alterations after administration by the intraperitoneal route, but doses given orally were innocuous to pregnant rats and their offspring.

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    • "The citotoxic effects of valepotriates in vitro were already demonstrated (Bounthanh et al., 1983; Lin et al., 2009). However, in vivo experiments have not demonstrated toxicity in rats orally administered with valepotriates (Tufik et al., 1994). In summary, literature data regarding the pharmacological activity of valepotriates are not very extensive and present some dissonant results. "
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    ABSTRACT: The antidepressant-like effect of a supercritical CO2 (SCCO2) Valeriana glechomifolia extract enriched in valepotriates was investigated in a mice tail suspension test (TST) and forced swimming test (FST). The SCCO2 extract decreased mice immobility in the FST (0.5-20 mg/kg p.o.) and elicited a biphasic dose-response relationship in the TST (1-20 mg/kg p.o.) with no alterations in locomotor activity and motor coordination (assessed in the open-field and rota-rod tests, respectively). The anti-immobility effect of the SCCO2 extract (5 mg/kg, p.o.) was prevented by mice pre-treatment with yohimbine (1 mg/kg, i.p., an α2 adrenoceptor antagonist), SCH 23390 (15 μg/kg, s.c., D1 dopamine receptor antagonist) and sulpiride (50 mg/kg, i.p., D2 dopamine receptor antagonist). However, mice pre-treatments with prazosin (1 mg/kg, i.p., α1 adrenoceptor antagonist) and p-chlorophenilalanine methyl ester (4×100 mg/kg/day, i.p., a serotonin synthesis inhibitor) were not able to block the anti-immobility effect of the SCCO2 extract. Administration (p.o.) of the SCCO2 extract (0.25 mg/kg) and imipramine (10 mg/kg), desipramine (5 mg/kg) and bupropion (3 mg/kg) at sub-effective doses significantly reduced mice immobility time in the FST. These data provide the first evidence of the antidepressant-like activity of V. glechomifolia valepotriates, which is due to an interaction with dopaminergic and noradrenergic neurotransmission.
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    • "The hatches were standardized by the number of animals per hatch: only four animals per hatch were left for subsequent observation. These animals consisted of 2 male and 2 female (Tufik et al., 1994). "
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    • "Likewise, ginseng extract has been shown to be completely non-toxic in acute and chronic toxicity tests with five animal models (Soldati, 1984; Bradley, 1992; Sonnenborn and Ha¨nsel, 1992; World Health Organisation, 1999) and is known to improve sperm production (Owen, 1981; World Health Organisation, 1999). In contrast, Tufik et al. (1994) reported a negative effect of valerian on reproduction, whilst Chan et al. (2003) observed direct teratogenic effects on rat embryos by a ginsenoside administered in amounts equivalent to normal human intake. "
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