Acetazolamide-induced nephrolithiasis: Implications for treatment of neuromuscular disorders

Neuromuscular Disease Center, University of Rochester School of Medicine and Dentistry, NY 14642.
Neurology (Impact Factor: 8.3). 07/1993; 43(6):1105-6. DOI: 10.1212/WNL.43.6.1105
Source: PubMed

ABSTRACT Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another, permitting continued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its use.