Article

IgE antibodies against bovine serum albumin in a case of eosinophilic gastroenteritis.

Immunology Service, Hospital Duran i Reynals, Barcelona, Spain.
Allergy (impact factor: 6.27). 11/1993; 48(7):542-6.
Source: PubMed

ABSTRACT Eosinophilic gastroenteritis is a disease characterized histologically by an eosinophilic infiltration of the gut. The cause of this disease remains unclear, although both food allergy and food intolerance have been implicated in its pathogenesis. We report the case of a 22-year-old man in whom gastrointestinal symptoms first appeared in childhood, with involvement of mucosa and muscularis layers of stomach and bowel. He presented high IgE blood levels, and his prick test was positive to bovine, pig, and lamb sera. Immunoblots from calf, pig, and lamb sera, incubated with the patient's serum and revealed by autoradiography, demonstrated the presence of a 65-kDa protein band that was recognized by IgE antibodies but not by IgG. This band corresponded to bovine serum albumin, while IgE did not show reactivity with human albumin. These data suggest a possible role for IgE-mediated hypersensitivity mechanisms in the pathogenesis of eosinophilic gastroenteritis.

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Keywords

22-year-old man
 
65-kDa protein band
 
autoradiography
 
band corresponded
 
eosinophilic gastroenteritis
 
eosinophilic infiltration
 
food allergy
 
human albumin
 
IgE antibodies
 
IgE blood levels
 
IgE-mediated hypersensitivity mechanisms
 
lamb sera
 
muscularis layers
 
possible role
 
prick test
 
reactivity