Article

Epirubicin and ifosfamide in advanced soft tissue sarcomas.

Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy.
Annals of Oncology (impact factor: 6.43). 10/1993; 4(8):669-72.
Source: PubMed

ABSTRACT To evaluate the feasibility, toxicity and efficacy of the combination of (IFO) ifosfamide and epirubicin (EPI) given at conventional doses for monochemotherapy, we started a phase II study in advanced/metastatic soft tissue sarcoma patients.
Treatment consisted of: epirubicin 75 mg/m2 i.v. day 1; IFO 1.8 g/m2 days 1 to 5; MESNA 20% of the IFO dose at 4-hour intervals three times a day during IFO administration. Cycles were given every 3-4 weeks for at least three cycles.
The overall response rate for non-visceral sarcomas (51 pts) was 31% (95% confidence limits +/- 13%). Among the 13 visceral sarcomas no response was seen for the leiomyosarcomas of the gastrointestinal tract, whereas one complete and one partial remission were observed for the uterine sarcomas. The duration of response was 10 months (range 5-34+) for complete responses and 9 (range 4-42+) for partial responses. The median survival for responders is 18 months (range 2-60+) and for non-responders 10 months (range 1-33) (p < 0.004).
This combination proved to be feasible and tolerable. The overall response rate does not appear to be superior to those with other standard treatments, but it should be pointed out that our patient population was totally unselected.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

13 visceral sarcomas
 
4-hour intervals
 
advanced/metastatic soft tissue sarcoma patients
 
complete
 
complete responses
 
conventional doses
 
Cycles
 
EPI
 
epirubicin
 
feasible
 
gastrointestinal tract
 
median survival
 
monochemotherapy
 
partial remission
 
partial responses
 
phase II study
 
standard treatments
 
three cycles
 
toxicity
 
uterine sarcomas
 

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