Article

[Multiple myeloma associated with diffuse parenchymal amyloidosis of the lung].

First Department of Internal Medicine, Tokyo Medical and Dental University.
[Rinshō ketsueki] The Japanese journal of clinical hematology 12/1993; 34(11):1497-9. pp.1497-9
Source: PubMed

ABSTRACT A 58-year-old woman was hospitalized in March, 1991, with slight breathlessness on exertion. Laboratory investigations revealed M-protein (IgG lambda type, 7,575mg/dl) in serum, and Bence-Jones proteinuria. Osteolytic bone lesions were noted roentgeno-logically. Bone marrow aspiration showed the presence of 19% of atypical plasma cells, and the case was diagnosed as multiple myeloma. The chest X-ray film showed bilateral diffuse micronodules, which were found by a transbronchial lung biopsy to be diffuse parenchymal amyloid deposits. The patient was treated with melphalan, prednisolone and interferon-alpha for 6 courses. Clinical symptoms improved but no decrease of the level of M-protein was observed. The patient is still alive without changes of pulmonary shadows on X-ray films for the past 2 years.

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Keywords

2 years
 
58-year-old woman
 
6 courses
 
atypical plasma cells
 
Bence-Jones proteinuria
 
bilateral diffuse micronodules
 
Bone marrow aspiration
 
chest X-ray film
 
diffuse parenchymal amyloid deposits
 
IgG lambda type
 
Laboratory investigations
 
M-protein
 
melphalan
 
Osteolytic bone lesions
 
slight breathlessness
 
transbronchial lung biopsy
 

K Hisauchi