Article

Anatomy and biomechanics of genital prolapse.

University of Michigan Medical School, Ann Arbor.
Clinical Obstetrics and Gynecology (Impact Factor: 1.84). 01/1994; 36(4):897-909. DOI: 10.1097/00003081-199312000-00015
Source: PubMed
1 Bookmark
 · 
180 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction. This study is a comparative evaluation of the TVT, TOT, and our own modification of TOT (mTOT) in the treatment of female stress urinary incontinence from a single center experience. Material and Methods. The study was conducted on 527 patients with SUI diagnosed on the basis of urodynamic studies. They were divided into three groups-TVT: n = 142, (TOT): n = 129, and mTOT: n = 256. All of the patients underwent evaluation at 1, 3, and 6 months after surgery. Results were statistically analysed and compared. Results. Objective and subjective effectiveness after the surgery were not significantly different in the study groups and ranged from 90.1% to 96.4%. Mean surgery time was 32.3, 28.2, and 26.4 in the TVT, TOT, and mTOT, respectively. Mean hospitalization time was 2.51 days. Mean catheter maintenance time was significantly higher in the TVT than in other groups. In the TVT group total incidence of complications was 13.4%, and it was significantly higher than that in TOT and mTOT (9.3% and 8.6%, resp.). Conclusions. TVT, TOT, and mTOT are highly effective and safe methods in the treatment of SUI. There are no differences in the efficacy between the methods with a little higher percentage of complications in the TVT group.
    BioMed research international. 01/2014; 2014:347856.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: La incontinencia urinaria femenina ha sido siempre un tema apasionante, en virtud de la prevalencia, la incidencia y las númerosas formas de tratamiento que tiene. Las experiencias vividas con un número importante de pacientes, indujo al autor a querer plasmar sus impresiones y poder con ello, contribuir a la formación de nuevos urólogos y ayudar en la mejor comprensión de una patología a la cual se le daba un enfoque terapeutico parcial, con usualmente un solo tipo de modalidad tratante, con el añadido de 655 referencias bibliográficas consultadas y plasmadas en el texto. Hoy en día se deben considerar muchos aspectos que rodean la vida de las pacientes afectadas de incontinencia urinaria, bien sea de esfuerzo, de urgencia o mixta. Se deberá igualmente considerar la multimodalidad de tratamiento, ya que ha demostrado dar los mejores resultados a largo plazo. Se deberán enfocar aspectos concernientesa a los hábitos de vida de la paciente, hábitos alimentarios, la manera de vivir, sus relaciones íntimás y sus relaciones con el medio ambiente laboral y familiar. Se deberán investigar tipos de enfermedades concomitantes que tiene la paciente y la cantidad y variedad de fármacos que pudiera estar tomando. Se le deberá dar una importancia capital al estado funciónal del piso pelviano muscular. Es de tal trascendencia que de su contráctilidad y buen funciónamiento, dependerá el éxito de la terapia quirúrgica y el éxito de las terapias no quirúrgicas. Siempre deberá estar en lugares de prioridad en los modelos de decisión en pacientes con incontinencia urinaria, bien sea de esfuerzo o mixta (de urgencia y de esfuerzo). El libro consta de dos capítulos, el primero habla de un enfoque general de las pacientes con incontinencia urinaria y el segundo, enfoca un tema apasionante, como es el tratamiento farmacológico de pacientes con incontinencia urinaria.
    11/2014;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Interferon (IFN)-γ is a potent proinflammatory molecule. However, few studies have investigated the expression levels of IFN-γ during pelvic organ prolapse (POP). In the present study, the expression levels and tissue localization of IFN-γ and its pathway-associated genes were detected in the vaginal walls of premenopausal females with POP and asymptomatic controls using quantitative polymerase chain reaction and immunohistochemistry. When compared with the matched controls, an 8.6-fold increase in IFN-γ, 3.8-fold increase in IFN-γ receptor (IFNGR)1, 2.6-fold increase in IFNGR2, 3.4-fold increase in signal transducer and activator of transcription-1, 2.2-fold increase in janus kinase-1 and 5.1-fold increase in nuclear factor (NF)-κB mRNA expression levels were observed in the females with premenopausal POP. In all the females with POP, higher mRNA expression levels of IFN-γ and its receptors were observed when compared with the controls. Expression levels of all the proteins were detected by immunohistochemistry, and the results demonstrated higher staining for IFN-γ, IFNGRs and pathway-associated genes in females with POP. Therefore, the results indicated that IFN-γ may be used as an inflammatory marker for POP development, and is associated with NF-κB.
    Experimental and therapeutic medicine 10/2014; 8(4):1145-1149. · 0.34 Impact Factor