Major Histocompatibility Complex Class I Deficiency Prolongs Islet Allograft Survival

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
Diabetes (Impact Factor: 8.1). 11/1993; 42(10):1520-7. DOI: 10.2337/diabetes.42.10.1520
Source: PubMed


Because of islet allograft rejection, nonimmunosuppressed pancreatic islet allotransplantation has been unsuccessful for the treatment of type I diabetes. The role of major histocompatibility complex class I antigen expression on islet allograft survival was evaluated with the use of mice homozygous for a beta 2-microglobulin gene disruption. These mice express little if any functional major histocompatibility complex class I antigen. When these major histocompatibility complex class I-deficient islets were used as donors in an allogenic murine transplantation model, islet allograft survival was markedly prolonged. These results demonstrate a major importance for the alloresponse directed against major histocompatibility complex class I antigen.

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